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Titolo:
Epstein-Barr virus associated diffuse large B-cell lymphoma complicated byautoimmune hemolytic anemia and pure red cell aplasia
Autore:
Katayama, H; Takeuchi, M; Yoshino, T; Munemasa, M; Tada, A; Soda, R; Takahashi, K;
Indirizzi:
Natl Sanatorium Minami Okayama Hosp, Dept Internal Med, Okayama 7010304, Japan Natl Sanatorium Minami Okayama Hosp Okayama Japan 7010304 7010304, Japan
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 3, volume: 42, anno: 2001,
pagine: 539 - 542
SICI:
1042-8194(200107)42:3<539:EVADLB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; SJOGRENS-SYNDROME; HYBRIDIZATION; EXPRESSION;
Keywords:
diffuse large B cell-lymphoma; Epstein-Barr virus; autoimmune haemolytic anemia; pure red cell aplasia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Takeuchi, M Natl Sanatorium Minami Okayama Hosp, Dept Internal Med, 4066 Hayashima Cho, Okayama 7010304, Japan Natl Sanatorium Minami Okayama Hosp 4066 Hayashima Cho Okayama Japan 7010304
Citazione:
H. Katayama et al., "Epstein-Barr virus associated diffuse large B-cell lymphoma complicated byautoimmune hemolytic anemia and pure red cell aplasia", LEUK LYMPH, 42(3), 2001, pp. 539-542

Abstract

A 53-year old man with systemic lymphadenopathy and hepatosplenomegaly wasdiagnosed with diffuse large B cell-lymphoma after inguinal lymph node biopsy. Anemia was noted, direct and indirect Coombs tests were positive, and the haptoglobin level was low. However, the bone marrow aspirate revealed erythroid aplasia. Cc-existing autoimmune haemolytic anemia (AIHA) and pure red cell aplasia (PRCA) were diagnosed. In situ hybridization with Epstein-Barr virus (EBV) encoded small RNA (EBER) showed positive findings in lymphoma cells. Southern blot hybridization revealed immunoglobulin heavy chain gene rearrangement and a clonal EBV terminal repeat, indicating monoclonal proliferation of EBV in infected B cells. The patient was treated with CHOP, resulting in a complete remission (CR). AIHA and PRCA subsided after 3 courses of chemotherapy. In conclusion, this case demonstrates not only the association of B-cell lymphoma with autoimmune disorders but also the involvement of EBV in these conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:12:45