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Titolo:
CAM-cytarabine, aclarubicin plus macrophage colony-stimulating factor in the treatment of acute myelogenous leukemia with trilineage dysplasia: Usefulness of in vitro apoptosis in leukemic cells
Autore:
Mori, M; Hatake, K; Tanaka, M; Takatoku, M; Matsumoto, Y; Uchida, M; Kametaka, N; Nagai, T; Terui, Y; Tomizuka, H; Muroi, K; Ozawa, K;
Indirizzi:
Japanese Fdn Canc Res, Canc Inst Hosp, Dept Med Oncol, Toshima Ku, Tokyo 1708455, Japan Japanese Fdn Canc Res Tokyo Japan 1708455 shima Ku, Tokyo 1708455, Japan
Titolo Testata:
LEUKEMIA & LYMPHOMA
fascicolo: 3, volume: 42, anno: 2001,
pagine: 387 - 391
SICI:
1042-8194(200107)42:3<387:CAPMCF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; M-CSF; POOR RESPONSE; CHEMOTHERAPY; MONOCYTE; DIFFERENTIATION; MYELODYSPLASIA; COMBINATION; SURVIVAL;
Keywords:
cytarabine; aclarubicin; macrophage colony-stimulating factor (M-CSF); acute myelogenous leukemia with trilineage dysplasia (AML-TLD); apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Hatake, K Japanese Fdn Canc Res, Canc Inst Hosp, Dept Med Oncol, Toshima Ku, 1-37-1 Kami Ikebukuro, Tokyo 1708455, Japan Japanese Fdn Canc Res 1-37-1Kami Ikebukuro Tokyo Japan 1708455
Citazione:
M. Mori et al., "CAM-cytarabine, aclarubicin plus macrophage colony-stimulating factor in the treatment of acute myelogenous leukemia with trilineage dysplasia: Usefulness of in vitro apoptosis in leukemic cells", LEUK LYMPH, 42(3), 2001, pp. 387-391

Abstract

A 67-year-old woman was treated for acute myelogenous leukemia with trilineage dysplasia (AML-TLD) by combination chemotherapy with cytarabine, aclarubicin plus macrophage colony-stimulating factor (M-CSF) (referred to as CAM therapy). Complete remission was achieved after two courses of CAM therapy. After coculture of her bone marrow mononuclear cells with M-CSF in vitro, differentiation of leukemic cells into macrophages with apoptotis was observed. This case confirms an earlier report that an effect of M-CSF inducible by differentiation with apoptotic phenomena, against human leukemic cells was shown both in vitro and in vivo when achieving complete remission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:56:38