Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CALCITRIOL AND BONE MASS ACCUMULATION IN FEMALES DURING PUBERTY
Autore:
ILICH JZ; BADENHOP NE; JELIC T; CLAIRMONT AC; NAGODE LA; MATKOVIC V;
Indirizzi:
OHIO STATE UNIV,DAVIS MED RES CTR,BONE & MINERAL METAB LAB,480 W 9TH AVE COLUMBUS OH 43210 OHIO STATE UNIV,DEPT VET BIOSCI COLUMBUS OH 43210
Titolo Testata:
Calcified tissue international
fascicolo: 2, volume: 61, anno: 1997,
pagine: 104 - 109
SICI:
0171-967X(1997)61:2<104:CABMAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM 1,25-DIHYDROXYVITAMIN-D LEVELS; PARATHYROID-HORMONE; SEXUAL-MATURATION; NORMAL-CHILDREN; CALCIUM; PHOSPHORUS; METABOLISM; ASSAY;
Keywords:
CALCITRIOL; PUBERTY; BONE MASS; OSTEOCALCIN; ADOLESCENT FEMALES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J.Z. Ilich et al., "CALCITRIOL AND BONE MASS ACCUMULATION IN FEMALES DURING PUBERTY", Calcified tissue international, 61(2), 1997, pp. 104-109

Abstract

Adolescence is characterized by rapid skeletal development and high demands for bone minerals. Though the stimulative effect of calcitriol on intestinal calcium and phosphorus absorption is well understood, its effect on bone development is not completely clear. It may be directly involved in the facilitation of calcium economy during this critical phase of skeletal development. Therefore, we evaluated the serum concentrations of calcitriol in relation to skeletal development in a cross-sectional study of 178 healthy Caucasian females during different pubertal stages, extending from childhood to young adulthood. In addition, a subsample of 57 younger girls was followed for a 1-year period to evaluate the association among serum calcitriol, nutrition parameters (dietary calcium, phosphorus, and vitamin D), bone mass accumulation, and biochemical markers of bone turnover. The serum calcitriol concentration in a cross-sectional sample was the highest during pubertal growth spurt (sexual maturity index 3-4, age 11-13 years) (ANOVA: F = 2.4945; P = 0.0329). This correlated to the peak skeletal calcium accretion (g/year) and bone mass accumulation in total body and forearm. Ina longitudinal sample, there was a positive association between annual change in TBBMC (P = 0.0255); TBBMD (P = 0.0168); proximal radius (1/3 distance from styloid process) BMC (P = 0.0096); BMD (P = 0.0541), and baseline calcitriol level in forward stepwise regression analyses. The results of the forward stepwise regression analyses with serum calcitriol as a dependent variable and different serum, urinary, and dietary parameters measured at baseline (age 11 years, n = 114) and after1 year (age 12 years, n = 57) showed that osteocalcin was positively associated with calcitriol in both years; more so in a second year (P = 0.0514, P < 0.0001, respectively). Dietary vitamin D and phosphorus showed negative association with serum calcitriol at age 11, and dietary Ca and P were selected at age 12. The results of this study show that calcitriol is a significant correlate of bone mass accumulation during pubertal growth, presumably in response to the high requirements for calcium during this critical phase of skeletal development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:16:16