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Titolo:
Biomarkers of apoptosis: Release of cytochrome c, activation of caspase-3,induction of 8-hydroxy-2 '-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene
Autore:
Abu-Qare, AW; Abou-Donia, MB;
Indirizzi:
Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Pharmacol & Canc Biol, Durham, NC 27710 USA
Titolo Testata:
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
fascicolo: 3, volume: 4, anno: 2001,
pagine: 313 - 332
SICI:
1093-7404(200107/09)4:3<313:BOAROC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXIDATIVE DNA-DAMAGE; PERFORMANCE LIQUID-CHROMATOGRAPHY; MASS-SPECTROMETRIC QUANTIFICATION; RESPIRATORY-DISTRESS SYNDROME; INDUCED NEURONAL APOPTOSIS; CEREBELLAR GRANULE CELLS; TYROSINE NITRATION; NITRIC-OXIDE; REACTIVE OXYGEN; IN-VITRO;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
170
Recensione:
Indirizzi per estratti:
Indirizzo: Abou-Donia, MB Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 c Biol, Durham, NC 27710 USA
Citazione:
A.W. Abu-Qare e M.B. Abou-Donia, "Biomarkers of apoptosis: Release of cytochrome c, activation of caspase-3,induction of 8-hydroxy-2 '-deoxyguanosine, increased 3-nitrotyrosine, and alteration of p53 gene", J TOX E H B, 4(3), 2001, pp. 313-332

Abstract

Biomarkers rely on biochemical, histological, morphological, and physiological changes in whole organisms. Their use is becoming an important tool toexamine changes at cellular and molecular levels, especially in nucleic acids and proteins. Biomarkers are used to measure exposure to a toxic agent,to detect severity of any toxic response, and to predict the possible outcome. Information on the mechanisms of action of toxicants can allow the development of potential biomarkers of effect and thus improvement of the riskassessment processes. Use of biomarkers as a tool to predict induction of apoptosis allows identification of biological signs that may indicate increased risk for disease. In cells undergoing apoptosis, the release of cytochrome c from the mitochondria to the cytoplasm and the activation of caspase-3, a key enzyme to execution stage of apoptotic pathway. have been studiedas biomarkers of cell death (apoptosis). Products of DNA fragmentation that either accumulate in the cellular tissues or are excreted in the urine are useful markers of DNA damage. The induction level of urinary or cellular level of 8-hydroxy-2-deoxyguanosine and 3-nitrotyrosine has been used as a marker to measure extent of DNA oxidative damage. Furthermore, alteration or overexpression of the p53 gene was considered an indication of apoptosis. This article reviews some of the aspects of biomarkers of apoptosis, indicating relevance of their uses to predict apoptosis following exposure to environmental toxicants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:26:23