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Titolo:
Predictive factors for development of the no-reflow phenomenon in patientswith reperfused anterior wall acute myocardial infarction
Autore:
Iwakura, K; Ito, H; Kawano, S; Shintani, Y; Yamamoto, K; Kato, A; Ikushima, M; Tanaka, K; Kitakaze, M; Hori, M; Higashino, Y; Fujii, K;
Indirizzi:
Sakurabashi Watanabe Hosp, Div Cardiol, Kita Ku, Osaka 5300001, Japan Sakurabashi Watanabe Hosp Osaka Japan 5300001 a Ku, Osaka 5300001, Japan Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Osaka, Japan Osaka Univ Osaka Japan Med, Dept Internal Med & Therapeut, Osaka, Japan
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
fascicolo: 2, volume: 38, anno: 2001,
pagine: 472 - 477
SICI:
0735-1097(200108)38:2<472:PFFDOT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY OCCLUSION; SUCCESSFUL THROMBOLYSIS; FLOW VELOCITY; ANGIOPLASTY; MORTALITY; ADENOSINE; PROTECTS; DISEASE; SALVAGE; DAMAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ito, H Sakurabashi Watanabe Hosp, Div Cardiol, Kita Ku, 2-4-32 Umeda, Osaka 5300001, Japan Sakurabashi Watanabe Hosp 2-4-32 Umeda Osaka Japan 5300001 , Japan
Citazione:
K. Iwakura et al., "Predictive factors for development of the no-reflow phenomenon in patientswith reperfused anterior wall acute myocardial infarction", J AM COL C, 38(2), 2001, pp. 472-477

Abstract

OBJECTIVES We sought to elucidate the clinical factors related to the development of no-reflow phenomenon after successful coronary reperfusion in patients with an acute myocardial infarction (AMI). BACKGROUND Myocardial contrast echocardiography revealed that the no-reflow phenomenon is observed in some patients with a reperfused AMI, and those patients usually have poor functional and clinical outcomes. It is still unknown what clinical factors are related to the development of the no-reflowphenomenon. METHODS Myocardial contrast echocardiography was performed 15 min after successful coronary reperfusion therapy in 199 patients with an anterior wallAMI who underwent successful coronary reperfusion with primary coronary angioplasty within 24 h after the onset of AMI. Multiple logistic regression analysis was used to identify independent predictors of the no-reflow phenomenon. RESULTS Seventy-nine patients showed the no-reflow phenomenon. Univariate analysis indicated that pre-infarction angina within 48 h before symptom onset, Killip class, Thrombolysis in Myocardial Infarction flow grade 0 on the initial coronary angiogram, the number of abnormal Q-waves and the wall motion score ( WS) on the echocardiogram obtained at hospital admission are related to the no-reflow phenomenon. Multivariate logistic regression analysis revealed that all of these factors, except fur Killip class, are independent predictive factors of the no-reflow phenomenon. CONCLUSIONS Development of the no-reflow phenomenon is related to the severity of myocardial damage (number of Q-waves), the size of the risk area (WMS) and the occlusion status of infarct-related artery. In addition, ischemic preconditioning (pre-infarction angina) seems to be the factor that attenuates the no-reflow phenomenon. (J Am Coll Cardiol 2001;38:472-7) 2001 by the American College of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 21:41:43