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Titolo:
Tumor necrosis factor promoter polymorphisms in patients with rheumatoid arthritis in Taiwan
Autore:
Yen, JH; Chen, CJ; Tsai, WC; Lin, CH; Ou, TT; Wu, CC; Liu, HW;
Indirizzi:
Kaohsiung Med Univ Hosp, Dept Internal Med, Div Rheumatol Allergy & Immunol, Kaohsiung, Taiwan Kaohsiung Med Univ Hosp Kaohsiung Taiwan y & Immunol, Kaohsiung, Taiwan Kaohsiung Municipal Hsiao Kang Hosp, Dept Internal Med, Kaohsiung, Taiwan Kaohsiung Municipal Hsiao Kang Hosp Kaohsiung Taiwan Kaohsiung, Taiwan
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 8, volume: 28, anno: 2001,
pagine: 1788 - 1792
SICI:
0315-162X(200108)28:8<1788:TNFPPI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-ALPHA GENE; SYSTEMIC LUPUS-ERYTHEMATOSUS; TNF-ALPHA; ANKYLOSING-SPONDYLITIS; 5'-FLANKING REGION; DIABETES-MELLITUS; ALLELE; ASSOCIATION; SUSCEPTIBILITY; IDENTIFICATION;
Keywords:
tumor necrosis factor; polymorphism; rheumatoid arthritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Yen, JH Kaohsiung Med Univ, Dept Internal Med, Div Rheumatol Allergy & Immunol, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan Kaohsiung Med Univ 100 Shih Chuan 1st Rd Kaohsiung Taiwan 807 wan
Citazione:
J.H. Yen et al., "Tumor necrosis factor promoter polymorphisms in patients with rheumatoid arthritis in Taiwan", J RHEUMATOL, 28(8), 2001, pp. 1788-1792

Abstract

Objective. To investigate the association of tumor necrosis factor (TNF) promoter polymorphisms with rheumatoid arthritis (RA) in Taiwan. Methods. TNF promoter polymorphisms at positions -238, -244, -308 -376, -857, and -863 were determined in 97 patients with RA and 97 healthy controlsusing the PCR-RFLP method. Results. The phenotypic frequency of TNF-308A was significantly lower in patients with RA than in healthy controls. This finding can only be found inHLA-DR4 negative patients, not in DR4 positive RA patients and controls. The TNF promoter polymorphisms at positions -238, -244, -308, -376, -857, and -863 were not related to the clinical manifestations of RA patients. Conclusion. TNF-308A itself or a neighboring gene may be a protective factor for the development of RA in the HLA-DR4 negative population in Taiwan. TNF promoter polymorphisms were not associated with the clinical manifestations of patients with RA in Taiwan.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:54:55