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Titolo:
NUCLEOSOMAL STRUCTURES OF C-MYC PROMOTERS WITH TRANSCRIPTIONALLY ENGAGED RNA-POLYMERASE-II
Autore:
ALBERT T; MAUTNER J; FUNK JO; HORTNAGEL K; PULLNER A; EICK D;
Indirizzi:
GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT GMBH,INST KLIN MOL BIOL & TUMORGENET,MARCHIONINISTR 25 D-81377 MUNICH GERMANY GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT GMBH,INST KLIN MOL BIOL & TUMORGENET D-81377 MUNICH GERMANY
Titolo Testata:
Molecular and cellular biology
fascicolo: 8, volume: 17, anno: 1997,
pagine: 4363 - 4371
SICI:
0270-7306(1997)17:8<4363:NSOCPW>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BURKITTS-LYMPHOMA CELLS; LIGATION-MEDIATED PCR; TUMOR VIRUS PROMOTER; IN-VIVO; CHROMATIN STRUCTURE; HEAT-SHOCK; DOWN-REGULATION; MMTV PROMOTER; 1ST EXON; DROSOPHILA-MELANOGASTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
80
Recensione:
Indirizzi per estratti:
Citazione:
T. Albert et al., "NUCLEOSOMAL STRUCTURES OF C-MYC PROMOTERS WITH TRANSCRIPTIONALLY ENGAGED RNA-POLYMERASE-II", Molecular and cellular biology, 17(8), 1997, pp. 4363-4371

Abstract

Organization of DNA into chromatin has been shown to contribute to a repressed state of gene transcription. Disruption of nucleosomal structure is observed in response to gene induction, suggesting a model in which RNA polymerase II (pol II) is recruited to the promoter upon reorganization of nucleosomes, Here we show that induction of c-myc transcription correlates with the disruption of two nucleosomes in the upstream promoter region. This nucleosomal disruption, however, is not necessary for the binding of pol II to the promoter, Transcriptionally engaged pol II complexes can be detected when the upstream chromatin is in a more closed configuration. Thus, upstream chromatin opening is suggested to affect activation of promoter-bound pol II rather than entry of polymerases into the promoter, Interestingly, pol II complexes are detectable in both sense and antisense transcriptional directions, but only complexes in the sense direction respond to activation signalsresulting in processive transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:38:05