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Titolo:
Kasai portoenterostomy: Differences related to race
Autore:
Lee, H; Lewis, J; Schoen, BT; Brand, T; Ricketts, RR;
Indirizzi:
Emory Univ, Childrens Healthcare Atlanta, Dept Surg, Atlanta, GA 30322 USAEmory Univ Atlanta GA USA 30322 Atlanta, Dept Surg, Atlanta, GA 30322 USA Emory Univ, Childrens Healthcare Atlanta, Dept Gastroenterol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Dept Gastroenterol, Atlanta, GA 30322 USA
Titolo Testata:
JOURNAL OF PEDIATRIC SURGERY
fascicolo: 8, volume: 36, anno: 2001,
pagine: 1196 - 1198
SICI:
0022-3468(200108)36:8<1196:KPDRTR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILIARY ATRESIA; LIVER-TRANSPLANTATION; EXPERIENCE; CHILDREN; MANAGEMENT;
Keywords:
biliary atresia; portoenterostomy; race; Kasai; outcome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Ricketts, RR Div Pediat Surg, 2040 Ridgewood Dr NE, Atlanta, GA 30322 USA Div Pediat Surg 2040 Ridgewood Dr NE Atlanta GA USA 30322 USA
Citazione:
H. Lee et al., "Kasai portoenterostomy: Differences related to race", J PED SURG, 36(8), 2001, pp. 1196-1198

Abstract

Purpose: The aim of this study was to evaluate the Kasai portoenterostomy in African-American and white children with respect to differences in presentation and outcome. Methods: A retrospective review of all children with biliary atresia who underwent a portoenterostomy at our institution over the last 15 years (n = 63) was performed. Sex, age at the time of Kasai, preoperative laboratory tests, success rates (defined as postoperative total serum bilirubin less than or equal to 2.0 mg/dL), and survival rate were recorded. Differences between African-American (AA; n = 30) and white (W; n = 33) children were analyzed. Long-term follow-up was available on 59 of 63 patients. Results: Sixty-three percent of ail patients (40 of 65) were girls, and 48% were AA (30 of 63). A higher percentage of AA children (73%) were girls than were white children (55%), although this difference did not achieve statistical significance. African-Americans underwent portoenterostomy at a later age, had higher alkaline phosphatase levels, and higher AST. These differences were statistically significant. Preoperative ALT, total bilirubin level, and GGTP levels all were greater in African-Americans, although thesedifferences did not achieve statistical significance. There was a trend toward decreased success and survival rate, although these results also were not statistically significant. Conclusions: African-Americans underwent primary therapeutic intervention for biliary atresia at an older age than white children with a trend towardless favorable results. These differences related to race may be attributed to greater difficulty in diagnosing jaundice or poorer access to health care in this patient population. Increased effort at identifying biliary atresia in AA children may lead to earlier diagnosis and treatment and improved outcomes. J Pediatr Surg 36:1196-1198. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 11:06:23