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Titolo:
Subchronic toxicity of fish oil concentrates in male and female rats
Autore:
Rabbani, PI; Alam, HZ; Chirtel, SJ; Duvall, RE; Jackson, RC; Ruffin, G;
Indirizzi:
US FDA, Ctr Food Safety & Appl Nutr, Washington, DC 20204 USA US FDA Washington DC USA 20204 fety & Appl Nutr, Washington, DC 20204 USA
Titolo Testata:
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
fascicolo: 3, volume: 47, anno: 2001,
pagine: 201 - 212
SICI:
0301-4800(200106)47:3<201:STOFOC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYUNSATURATED FATTY-ACIDS; LOW-DENSITY LIPOPROTEINS; LDL RECEPTOR ACTIVITY; CARDIOVASCULAR-DISEASE; PLASMA-LIPIDS; HEART-DISEASE; MENHADEN OIL; OMEGA-3 PUFA; CORN-OIL; LIVER;
Keywords:
subchronic toxicity; fish oil concentrates; n-3 fatty acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Rabbani, PI US FDA, Ctr Food Safety & Appl Nutr, HFS-308,200 C St SW, Washington, DC 20204 USA US FDA HFS-308,200 C St SW Washington DC USA 20204 C 20204 USA
Citazione:
P.I. Rabbani et al., "Subchronic toxicity of fish oil concentrates in male and female rats", J NUTR SC V, 47(3), 2001, pp. 201-212

Abstract

There are an overwhelming number of reports indicating the beneficial effects of fish oil supplements in human and animal nutrition. The purpose of this study, second in a series, was to evaluate the effects, particularly those that may be harmful, of high-dose, long-term consumption of fish oil concentrates (FOC) using male and female rats. One hundred and twenty male and 120 female rats were gavaged daily with oils and oil mixtures in a volumeequal to 0.5% body weight (5 mL/kg/d) for 13 weeks. The administered oils were corn oil, pure menhaden oil (MO), pure MaxEPA(R) fish oil or differentmixtures of corn oil with MO. The stability and the homogeneity of the dosing solutions were tested under study conditions. The animals received isocaloric and isonitrogenous diets throughout. Food and pure water were supplied ad libitum. At the end of the in-life phase of the study, the animals were anaesthetized with CO2 and humanely killed by exsanguination. Blood and other tissues were prepared for various clinical, histopathological and laboratory tests. Some beneficial effects of FOC, such as reduction in total serum cholesterol, in rats were confirmed. However, we also observed a significant reduction in absolute amount of serum HDL and a significant increasein relative liver and spleen weights in both sexes with the high dose of FOC. High doses of FOC (5 mL/kg/d) reduced serum iron and vitamin E concentrations. A reduction in osmotic fragility of RBC as well as an increase in RBC deformity were also observed in rats treated with high doses of FOC. These rats showed a significant overall increase in WBC count. We conclude that in rats, subchronic consumption of high levels of FOC can be beneficial but may also be harmful because of induction of clinical abnormalities including increased red cell deformity, increased relative liver and spleen weights, and reduced serum HDL, iron and vitamin E concentrations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:36:54