Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Multiparametric monitoring of brain under elevated intracranial pressure in a rat model
Autore:
Barbiro-Micahely, E; Mayevsky, A;
Indirizzi:
Bar Ilan Univ, Fac Life Sci, IL-52900 Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel IL-52900 Sci, IL-52900 Ramat Gan, Israel
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 7, volume: 18, anno: 2001,
pagine: 711 - 725
SICI:
0897-7151(200107)18:7<711:MMOBUE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-DOPPLER FLOWMETRY; CEREBRAL BLOOD-FLOW; CEREBROSPINAL-FLUID; INTRAOPERATIVE MEASUREMENT; CARBON-MONOXIDE; HEAD-INJURY; AUTOREGULATION; HYPERTENSION; RESPONSES; MICROCIRCULATION;
Keywords:
cerebral blood flow; cisternal infusion; intracranial hypertension; NADH redox state; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Mayevsky, A Bar Ilan Univ, Fac Life Sci, IL-52900 Ramat Gan, Israel Bar Ilan Univ Ramat Gan Israel IL-52900 00 Ramat Gan, Israel
Citazione:
E. Barbiro-Micahely e A. Mayevsky, "Multiparametric monitoring of brain under elevated intracranial pressure in a rat model", J NEUROTRAU, 18(7), 2001, pp. 711-725

Abstract

Intracranial hypertension may develop in most patients exposed to traumatic head injury. In many cases, patients enduring elevated intracranial pressure (ICP) will incur morbidity or mortality. Several methods are used in animal models to investigate the influence of ICP elevation on physiological parameters. In this study, we developed a cisterna magna model by adding a mechanism for warming the mock cerebrospinal fluid (CSF) entering the cisterna space to a temperature of 37 degreesC and combined this method for ICP elevation with the multiparametric monitoring system (Multiprobe Assembly [MPA]). Using the MPA, we monitored, for the first time, mitochondrial NADH redox state as well as ionic homeostasis under elevated ICP in a rat model. In addition, we monitored cerebral blood flow (CBF) by laser Doppler flowmetry, ECoG (bipolar electrodes), and surface temperature. Blood pressure was measured in the cannulated femoral artery. The ICP (monitored by Camino probe) was elevated to 50-60 mm Hg for 13-15 min, followed by 2 h of recovery. The results show that CBF was decreased by 90%, while NADH was elevated by 80% as compared to the normoxic levels. Complete depolarization occurredas evidence by the decrease in extracellular Ca2+ and a significant increase in K+. All parameters recovered 10 min after reopening the cannula to the cisterna magna to air pressure. We conclude that ICP elevation through the cisterna magna infusion method, used simultaneously with multiparametric monitoring, supplies reliable information on the brain tissue metabolic state with intracranial hypertension in a rat model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:45:17