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Titolo:
Delayed hemispheric neuronal loss in severely head-injured patients
Autore:
Shiozaki, T; Akai, H; Taneda, M; Hayakata, T; Aoki, M; Oda, J; Tanaka, H; Hiraide, A; Shimazu, T; Sugimoto, H;
Indirizzi:
Osaka Univ, Sch Med, Dept Traumatol, Suita, Osaka 565, Japan Osaka Univ Suita Osaka Japan 565 Dept Traumatol, Suita, Osaka 565, Japan Kinki Univ, Sch Med, Dept Neurosurg, Osaka 589, Japan Kinki Univ Osaka Japan 589 iv, Sch Med, Dept Neurosurg, Osaka 589, Japan
Titolo Testata:
JOURNAL OF NEUROTRAUMA
fascicolo: 7, volume: 18, anno: 2001,
pagine: 665 - 674
SICI:
0897-7151(200107)18:7<665:DHNLIS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRAUMATIC BRAIN INJURY; AMYLOID PROTEIN; ISCHEMIA; DEATH; RAT; HYPOTHERMIA; DAMAGE;
Keywords:
cerebral atrophy; delayed neuronal loss; head injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Shiozaki, T Osaka Univ, Sch Med, Dept Traumatol, 2-2 Yamadaoka, Suita, Osaka 565, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 565 saka 565, Japan
Citazione:
T. Shiozaki et al., "Delayed hemispheric neuronal loss in severely head-injured patients", J NEUROTRAU, 18(7), 2001, pp. 665-674

Abstract

Recent experimental studies have revealed that traumatic brain injury as well as ischemic brain injury can cause chronic progressive neuronal damage. In the present study, we demonstrate previously unreported delayed cerebral atrophy on computerized tomography (CT) scans in severely head-injured patients. Seventeen severely head-injured patients who required mild hypothermia to control intracranial hypertension after the failure of conventional therapies were retrospectively analyzed. All 17 patients survived more than1 year. Delayed neuronal loss (DNL) was observed in only eight of the 17 patients. Eight patients with DNL required longer durations of mild hypothermia to control intracranial hypertension than nine patients without DNL. Six of these eight patients with DNL achieved functional recovery despite progressive atrophic changes demonstrated on CT scans. On CT scans, DNL was characterized by (1) the sudden appearance at several months postinjury of a low-density area in the hemisphere ipsilateral to the injury; (2) the preservation of essential cortical structure although related white matter structures showed severe atrophic changes; and (3) no spread of the low-density area to the contiguous territory of the other main cerebral artery. It is concluded that focal primary injury to underlying brain, if severe enough, can result in delayed hemispheric atrophy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:29:28