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Titolo:
Concomitant occurrence of macroprolactin, exercise-induced amenorrhea, anda pituitary lesion: a diagnostic pitfall - Case report
Autore:
Cattaneo, FA; Fahie-Wilson, MN;
Indirizzi:
Univ Hosp Bern, Dept Endocrinol & Diabetol, CH-3010 Bern, Switzerland UnivHosp Bern Bern Switzerland CH-3010 betol, CH-3010 Bern, Switzerland Southend Hosp, Dept Clin Chem, Westcliff On Sea, England Southend Hosp Westcliff On Sea England Chem, Westcliff On Sea, England
Titolo Testata:
JOURNAL OF NEUROSURGERY
fascicolo: 2, volume: 95, anno: 2001,
pagine: 334 - 337
SICI:
0022-3085(200108)95:2<334:COOMEA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT PROLACTIN; BIG BIG PROLACTIN; ASYMPTOMATIC HYPERPROLACTINEMIA; IDIOPATHIC HYPERPROLACTINEMIA; POLYETHYLENE-GLYCOL; SIZE HETEROGENEITY; IMMUNOGLOBULIN-G; PRL; COMPLEX; PRECIPITATION;
Keywords:
pituitary surgery; apparent hyperprolactinemia; macroprolactin; big-big prolactin; amenorrhea;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Cattaneo, FA Via Soldino 7, CH-6900 Lugano, Switzerland Via Soldino 7 Lugano Switzerland CH-6900 ugano, Switzerland
Citazione:
F.A. Cattaneo e M.N. Fahie-Wilson, "Concomitant occurrence of macroprolactin, exercise-induced amenorrhea, anda pituitary lesion: a diagnostic pitfall - Case report", J NEUROSURG, 95(2), 2001, pp. 334-337

Abstract

The authors report the case of a 37-year-old woman who presented with amenorrhea and an increased level of serum prolactin. Magnetic resonance imagesof the pituitary revealed a lesion with characteristics consistent with those of a microadenoma. Transsphenoidal exploration was performed, but a prolactinoma was not found. After endocrinological review, the patient's hyperprolactinemia was found to be caused by the presence of macroprolactin and her amenorrhea was due to intense exercise and low body weight. Macroprolactin is an isoform of prolactin that is variably reactive in assays for prolactin, but displays minimum bioactivity in vivo. Patients with macroprolactin are mostly asymptomatic. This phenomenon may cause elevated prolactin values, which the authors view as apparent hyperprolactinemia. The presence of macroprolactin is an underrecognized problem, occurring in as many as 15 to 20% of patients with elevated prolactin values and often leading to unnecessary, expensive diagnostic procedures and inappropriate treatment. The presence of macroprolactin should always be suspected when the patient's clinical history or clinical or radiological data are incompatible with the prolactin value. Physicians dealing with diagnosis and treatment of hyperprolactinemia (general practitioners, gynecologists, neurosurgeons, endocrinologists, and biochemists) should be aware of the potentially misleading nature of macroprolactin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 22:57:33