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Titolo:
Diagnostic value of Tl-201-single-photon emission computerized tomography studies in cases of posterior fossa hemangioblastomas
Autore:
Kondo, T; Kumabe, T; Maruoka, S; Yoshimoto, T;
Indirizzi:
Tohoku Univ, Sch Med, Dept Neurosurg, Sendai, Miyagi 9808574, Japan TohokuUniv Sendai Miyagi Japan 9808574 rg, Sendai, Miyagi 9808574, Japan Tohoku Univ, Sch Med, Dept Radiol, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 ol, Sendai, Miyagi 9808574, Japan
Titolo Testata:
JOURNAL OF NEUROSURGERY
fascicolo: 2, volume: 95, anno: 2001,
pagine: 292 - 297
SICI:
0022-3085(200108)95:2<292:DVOTEC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TL-201 UPTAKE; BRAIN-TUMORS; MALIGNANCY; GLIOMA; SPECT;
Keywords:
hemangioblastoma; thallium-201; single-photon emission computerized tomography; retention index;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kumabe, T Tohoku Univ, Sch Med, Dept Neurosurg, 1-1 Seiryo Machi, Sendai, Miyagi 9808574, Japan Tohoku Univ 1-1 Seiryo Machi Sendai Miyagi Japan 9808574 , Japan
Citazione:
T. Kondo et al., "Diagnostic value of Tl-201-single-photon emission computerized tomography studies in cases of posterior fossa hemangioblastomas", J NEUROSURG, 95(2), 2001, pp. 292-297

Abstract

Object. The Tl-201 uptake index was evaluated for its usefulness in formulating a diagnosis of hemangioblastoma. Thallium-201-single-photon emission computerized tomography (SPECT) studies were performed in nine patients harboring hemangioblastomas in the posterior fossa and in five patients (six lesions) with gliomas in the posterior fossa. Methods. The Tl-201 uptake index was defined as the ratio of mean counts of isotope per pixel in the tumor to mean counts of isotope per pixel in thehomologous region of the healthy brain. The Tl-201 uptake indices of the early image (Tl-E) and that of the delayed image (Tl-D) were calculated. Theisotope retention index (RI) was calculated as (Tl-E - Tl-D)/Tl-E The Tl-Ewas 2.7 +/- 0.7 in hemangioblastomas and 2.9 +/- 1.7 in gliomas (mean standard deviation). The Tl-D was 1.5 +/- 0.4 in hemangioblastomas and 2.4 +/- 1.6 in gliomas. There were no significant differences between hemangioblastomas and gliomas when Tl(E)s and Tl(D)s were compared. The isotope RI was 0.43 +/- 0.07 in hemangioblastomas and 0.15 +/- 0.1 in gliomas, showing a significantly higher RI in hemangioblastomas compared with gliomas (p < 0.01). Conclusions, Thallium-201 washout is significantly faster in hemangioblastomas. Hemangioblastoma is biologically benign, but contains a rich capillary network that forms a hypervascular tumor bed. Variations in its appearance on magnetic resonance images may cause difficulties in the differential diagnosis of hemangioblastoma. Thallium-201 SPECT studies can be used to distinguish hemangioblastomas from gliomas in the posterior fossa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:30:13