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Titolo:
Enhancement of the response to levodopa therapy after intrastriatal transplantation of autologous sympathetic neurons in patients with Parkinson disease
Autore:
Nakao, N; Kakishita, K; Uematsu, Y; Yoshimasu, T; Bessho, T; Nakai, K; Naito, Y; Itakura, T;
Indirizzi:
Wakayama Med Univ, Dept Neurol Surg, Wakayama 6410012, Japan Wakayama Med Univ Wakayama Japan 6410012 l Surg, Wakayama 6410012, Japan Wakayama Med Univ, Dept Cardiovasc Thorac Surg, Wakayama 6410012, Japan Wakayama Med Univ Wakayama Japan 6410012 c Surg, Wakayama 6410012, Japan
Titolo Testata:
JOURNAL OF NEUROSURGERY
fascicolo: 2, volume: 95, anno: 2001,
pagine: 275 - 284
SICI:
0022-3085(200108)95:2<275:EOTRTL>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID DECARBOXYLASE; ENDOSCOPIC TRANSTHORACIC SYMPATHECTOMY; FETAL NIGRAL TRANSPLANTATION; SUPERIOR CERVICAL-GANGLION; EXOGENOUS L-DOPA; CAUDATE-NUCLEUS; INTRANIGRAL APPLICATION; MONOAMINE TRANSPORTER; AGONIST MUSCIMOL; SUBSTANTIA-NIGRA;
Keywords:
thoracic sympathetic ganglion; vesicular monoamine transporter-2; aromatic L-amino acid decarboxylase; Parkinson disease; dopamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Nakao, N Wakayama Med Univ, Dept Neurol Surg, Wakayama 6410012, Japan Wakayama Med Univ Wakayama Japan 6410012 akayama 6410012, Japan
Citazione:
N. Nakao et al., "Enhancement of the response to levodopa therapy after intrastriatal transplantation of autologous sympathetic neurons in patients with Parkinson disease", J NEUROSURG, 95(2), 2001, pp. 275-284

Abstract

Object. There is growing evidence to indicate that tissue transplantation can potentially be a restorative neurosurgical treatment for patients with Parkinson disease (PD). In this study the authors investigated the clinicaleffect of unilateral intrastriatal grafting of autologous sympathetic neurons in patients with PD. Methods. Four patients with PD who had been observed for I year after graft placement of autologous sympathetic neurons were selected for an analysisof the effect of that procedure. Sympathetic ganglion tissue was endoscopically excised from the thoracic sympathetic trunk and grafted into the unilateral caudate head and putamen of the PD patients. No changes were made inthe patients' preoperative regimens of antiparkinsonian medications, and clinical evaluations were made principally according to those established bythe Core Assessment Program for Intracerebral Transplantation Committee. Whereas the sympathetic neuron grafts failed to affect clinical scores reflecting the patients' motor performance, which was evaluated during either the "on" or "off" phases, the grafts significantly increased the duration of the levodopa-induced on period with consequent reduction in the percentage of time spent in the off phase. This beneficial effect may be explained by the results of the present in vitro experiment, which show that human sympathetic neurons have the ability to convert exogenous levodopa to dopamineand to store this synthesized dopamine. Conclusions. Sympathetic neuron autografts were found to improve performance status in patients with PD by reducing the time spent in the off phase. This clearly indicates that sympathetic ganglion tissue, the use of which involves few ethical issues, can be an efficacious donor source in cell transplantation therapy for PD, Further studies are needed to determine whetherthe grafts may provide long-lasting clinical benefits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:54:00