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Titolo:
Role of GluR2 expression in AMPA-induced toxicity in cultured murine cerebral cortical neurons
Autore:
Jensen, JB; Lund, TM; Timmermann, DB; Schousboe, A; Pickering, DS;
Indirizzi:
Royal Danish Sch Pharm, Dept Pharmacol, Neurosci Pharmabiotech Res Ctr, DK-2100 Copenhagen, Denmark Royal Danish Sch Pharm Copenhagen Denmark DK-2100 00 Copenhagen, Denmark
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 3, volume: 65, anno: 2001,
pagine: 267 - 277
SICI:
0360-4012(20010801)65:3<267:ROGEIA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL-NEURONS; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTORS; METHYL-D-ASPARTATE; JORO SPIDER TOXIN; NEOCORTICAL NEURONS; CA2+-PERMEABLE AMPA; CA2+ PERMEABILITY; INTRACELLULAR CALCIUM; SUBUNIT EXPRESSION; KAINATE RECEPTORS;
Keywords:
cyclothiazide; philanthotoxin; spermine; calcium; AMPA receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Pickering, DS Royal Danish Sch Pharm, Dept Pharmacol, Neurosci Pharmabiotech Res Ctr, 2 Univ Pk, DK-2100 Copenhagen, Denmark Royal Danish Sch Pharm 2Univ Pk Copenhagen Denmark DK-2100
Citazione:
J.B. Jensen et al., "Role of GluR2 expression in AMPA-induced toxicity in cultured murine cerebral cortical neurons", J NEUROSC R, 65(3), 2001, pp. 267-277

Abstract

alpha -Amino-3-hydroxy-5-methyl-4-isoxazoleproplonic acid receptor (AMPA-R)-mediated neurotoxicity was studied in relation to subunit expression and the presence of Ca2+-permeable receptor channels. AMPA-mediated toxicity had two components: 1) a direct AMPA-R-mediated component, which was not due to Ca2+ influx through voltage-gated Ca2+ channels, reversal of the Na+/Ca2 exchanger or release of calcium from dantrolene-sensitive intracellular Ca2+ stores, and 2) a minor, indirect component involving activation of NMDAreceptor channels, because of glutamate release and removal of the Mg2+ block of the NMDA receptor on AMPA-R stimulation. The involvement of Ca2+ influx through AMPA-R was also examined. The number of neurons possessing Ca2+-permeable AMPA-R increased during culture development, concurrently with an increasing susceptibility for AMPA-induced toxicity during development. GluR2(R) levels also increased during development, and channel blockers of Ca2+-permeable AMPA-R lacking the GluR2(R) subunit (spermine and philanthotoxin) failed to prevent neurotoxicity or increases in [Ca2+](i). Thus, the direct AMPA-R-mediated toxicity may be explained by initiation of cell deathby Ca2+ fluxing through AMPA-R containing GluR2(R). The components of direct AMPA-R-mediated toxicity are proposed to be 1) toxicity mediated by GluR2(R)-lacking AMPA-R and 2) toxicity mediated by low-Ca2+-permeability AMPA-R containing GluR2(R). J. Neurosci. Res. 65:267-277, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 00:03:27