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Titolo:
Tyrosine hydroxylase and dopamine transporter expression in residual dopaminergic neurons: Potential contributors to spontaneous recovery from experimental Parkinsonism
Autore:
Rothblat, DS; Schroeder, JA; Schneider, JS;
Indirizzi:
Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 3, volume: 65, anno: 2001,
pagine: 254 - 266
SICI:
0360-4012(20010801)65:3<254:THADTE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MPTP-INDUCED PARKINSONISM; VENTRAL TEGMENTAL AREA; MESSENGER-RNA; SUBSTANTIA-NIGRA; GENE-EXPRESSION; N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; INSITU HYBRIDIZATION; REGIONAL DIFFERENCES; FUNCTIONAL RECOVERY; VOLUME TRANSMISSION;
Keywords:
striatum; substantia nigra; ventral tegmental area; dopamine; retrorubral area;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Schneider, JS Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, 1020 Locust St,521 JAH, Philadelphia, PA 19107 USA Thomas Jefferson Univ 1020 Locust St,521 JAH Philadelphia PA USA 19107
Citazione:
D.S. Rothblat et al., "Tyrosine hydroxylase and dopamine transporter expression in residual dopaminergic neurons: Potential contributors to spontaneous recovery from experimental Parkinsonism", J NEUROSC R, 65(3), 2001, pp. 254-266

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahyrdropyridine (MPTP)exposed cats develop severe Parkinsonism that spontaneously resolves in 4-6 weeks. The present study examined the extent to which compensatory changes in tyrosine hydroxylase (TH) and dopamine transporter (DAT) gene and protein expression may underlie this behavioral recovery. In normal cats, TH and DAT protein levels were higher in the dorsal vs. ventral striatum. Expression of DAT and TH mRNAwas higher in substantia nigra pars compacta (SNc) than in the ventral tegmental area (VTA). In symptomatic parkinsonian animals, DAT and TH protein levels were significantly decreased in all striatal areas studied. TH and DAT mRNA expression in residual SNc neurons were decreased a mean 32% and 38%, respectively. DAT gene expression in residual VTA neurons in symptomaticanimals was decreased 30% whereas TH gene expression was unaffected. In spontaneously recovered cats, TH protein levels were significantly higher than the levels in symptomatic cats only in the ventral striatum, whereas no increase in DAT protein levels were observed in any striatal area. Residual neurons in most ventral mesencephalic regions of recovered cats had increased TH mRNA expression but not increased DAT gene expression, compared with symptomatic animals. Thus, increased TH protein and mRNA and suppression ofDAT protein and mRNA expression in the striatum and ventral mesencephalon were associated with functional recovery from MPTP-induced parkinsonism. J. Neurosci. Res. 65:254-266, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 18:13:05