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Titolo:
Administration of FGF-2 to embryonic mouse brain induces hydrocephalic brain morphology and aberrant differentiation of neurons in the postnatal cerebral cortex
Autore:
Ohmiya, M; Fukumitsu, H; Nitta, A; Nomoto, H; Furukawa, Y; Furukawa, S;
Indirizzi:
Gifu Pharmaceut Univ, Mol Biol Lab, Gifu 5028585, Japan Gifu Pharmaceut Univ Gifu Japan 5028585 ol Biol Lab, Gifu 5028585, Japan Soka Univ, Inst Life Sci, Immunosci Div, Tokyo, Japan Soka Univ Tokyo Japan Univ, Inst Life Sci, Immunosci Div, Tokyo, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 3, volume: 65, anno: 2001,
pagine: 228 - 235
SICI:
0360-4012(20010801)65:3<228:AOFTEM>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; HIPPOCAMPAL-NEURONS; NEUROTROPHIC FACTOR; TYROSINE-HYDROXYLASE; NESTIN EXPRESSION; NERVOUS-SYSTEM; MESSENGER-RNAS; STEM-CELLS; ADULT-RAT; PROTEIN;
Keywords:
fibroblast growth factor-2; mouse; cerebral cortex; development; brain-derived neurotrophic factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Furukawa, S Gifu Pharmaceut Univ, Mol Biol Lab, Gifu 5028585, Japan Gifu Pharmaceut Univ Gifu Japan 5028585 Gifu 5028585, Japan
Citazione:
M. Ohmiya et al., "Administration of FGF-2 to embryonic mouse brain induces hydrocephalic brain morphology and aberrant differentiation of neurons in the postnatal cerebral cortex", J NEUROSC R, 65(3), 2001, pp. 228-235

Abstract

Fibroblast growth factor-2 (FGF-2) was injected into mouse cerebral ventricles at embryonic day (E) 14 in utero, and its effects on developing brain morphology and expression of various cell- or differentiation-associated protein markers in the cerebral cortex were examined. High doses of FGF-2 (200 or 300 ng) caused encephalic alternations such as deformation of the calvarium, enlargement of the ventricular spaces, and thinning of the cerebral cortex. There was no gross abnormality in the alignment of the cerebral neuronal layers, however, both cell number and cell density of the upper layers (II/III) and the lower layers (IV-VI) of the cerebral cortex were increased. Brain-derived neurotrophic factor (BDNF), tyrosine hydroxylase, nestin,and microtubule-associated protein 2 were aberrantly or ectopically expressed in the deep areas of the cerebral cortex. A substantial number of thesecells coexpressed these antigens. These observations demonstrate that a subpopulation of neurons in the cortical deep layer abnormally differentiatedor partly sustained their immature state following a single administrationof FGF-2 at E14. Developmental analysis of localization of BDNF-positive cells suggested that the abnormality started around P5. Furthermore, cell migration was not affected by FGF-2 administration. FGF-2 seems to play predominant roles in the proliferation of neuronal precursors and in neuronal differentiation in the developing mouse cerebral cortex even at relatively late stages of brain neurogenesis. J. Neurosci. Res. 65: 228-235, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:49:01