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Titolo:
Disturbed benzodiazepine receptor function at the onset of temporal lobe epilepsy - Iomazenil-binding in de-novo TLE
Autore:
Matheja, P; Ludemann, P; Kuwert, T; Weckesser, M; Kellinghaus, C; Weitemeyer, L; Diehl, B; Schuierer, G; Ringelstein, EB; Schober, O;
Indirizzi:
WWU Muenster, Nukl Med Klin & Poliklin, D-48129 Munster, Germany WWU Muenster Munster Germany D-48129 Poliklin, D-48129 Munster, Germany WWU Muenster, Dept Neurol, D-48129 Munster, Germany WWU Muenster MunsterGermany D-48129 pt Neurol, D-48129 Munster, Germany WWU Muenster, Dept Clin Radiol, D-48129 Munster, Germany WWU Muenster Munster Germany D-48129 in Radiol, D-48129 Munster, Germany
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 7, volume: 248, anno: 2001,
pagine: 585 - 591
SICI:
0340-5354(200107)248:7<585:DBRFAT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIAL SEIZURES; HIPPOCAMPAL SCLEROSIS; FLUMAZENIL-PET; GLUCOSE CONSUMPTION; SPECT; MRI; AUTORADIOGRAPHY; ASYMMETRIES; DURATION;
Keywords:
benzodiazepine receptor binding; GABA(A) receptor complex; de-novo epilepsy; temporal lobe epilepsy; SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Matheja, P WWU Muenster, Nukl Med Klin & Poliklin, Albert Schweitzer Str 33, D-48129 Munster, Germany WWU Muenster Albert Schweitzer Str 33 Munster Germany D-48129
Citazione:
P. Matheja et al., "Disturbed benzodiazepine receptor function at the onset of temporal lobe epilepsy - Iomazenil-binding in de-novo TLE", J NEUROL, 248(7), 2001, pp. 585-591

Abstract

Purpose Epileptogenic foci exhibit disturbed function at the level of the benzodiazepine receptor. The aim of our study was to investigate the incidence of focal reductions of temporal benzodiazepine receptor binding (BRB) as assessed by scintigraphy with I-123-iomazenil in patients with denovo temporal lobe epilepsy (TLE). Methods Forty adult patients (age: 34 +/- 12 years) with cryptogenic denovo TLE underwent scintigraphy with I-123-iomazenil. In all patients, symptomatic epilepsy was excluded by clinical investigation and MRI. The median duration of TLE was seven months, and the patients had a median of three documented seizures in their history of disease. BRB was quantified in four temporal regions covering the whole temporal lobe. Temporal asymmetry values (ASY) were compared with data determined in 13 age-matched controls yielding Z-scores for global and regional temporal BRB. Results A significant reduction of temporal BRB was found in 19 of the 40 patients (48%), mainly in mesial temporal regions; temporal BRB asymmetries were also found in patients with a short history of seizures and low seizurefrequency (less than or equal to l1year; n = 32,13/32 (41%)). Only in the entire cohort did the magnitude of temporal reduction of BRB correlate withthe duration of TLE as well as with the number of previous partial seizures (r = 0.40 and r = 0.36; p < 0.03, respectively). Conclusions Foci of decreased BRB can already be detected at the onset of TLE; their magnitude is related to ongoing epileptic activity.

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Documento generato il 21/01/20 alle ore 07:50:21