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Titolo:
Neurological complications of primary Sjogren's syndrome
Autore:
Lafitte, C; Amoura, Z; Cacoub, P; Pradat-Diehl, P; Picq, C; Salachas, F; Leger, JM; Piette, JC; Delattre, JY;
Indirizzi:
Hop La Pitie Salpetriere, Federat Neurol Mazarin, F-75651 Paris 13, FranceHop La Pitie Salpetriere Paris France 13 zarin, F-75651 Paris 13, France Hop La Pitie Salpetriere, Dept Internal Med, F-75651 Paris, France Hop La Pitie Salpetriere Paris France F-75651 Med, F-75651 Paris, France Hop La Pitie Salpetriere, Dept Neurol Rehabil, F-75651 Paris 13, France Hop La Pitie Salpetriere Paris France 13 habil, F-75651 Paris 13, France
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 7, volume: 248, anno: 2001,
pagine: 577 - 584
SICI:
0340-5354(200107)248:7<577:NCOPSS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM DISEASE; ACUTE TRANSVERSE MYELOPATHY; PERIPHERAL NEUROPATHY; NEUROPSYCHIATRIC DYSFUNCTION; LUPUS-ERYTHEMATOSUS; REVISED CRITERIA; SICCA COMPLEX; INVOLVEMENT; CLASSIFICATION; SPECTRUM;
Keywords:
primary Sjogren's syndrome; peripheral neuropathy; cognitive impairment; myelopathy; motor neuron syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Lafitte, C Hop La Pitie Salpetriere, Federat Neurol Mazarin, 47 Blvd Hop, F-75651 Paris 13, France Hop La Pitie Salpetriere 47 Blvd Hop Paris France13 3, France
Citazione:
C. Lafitte et al., "Neurological complications of primary Sjogren's syndrome", J NEUROL, 248(7), 2001, pp. 577-584

Abstract

Objective: To better delineate the spectrum of neurological complications of primary Sjogren's syndrome (PSS). Methods: A detailed neurological investigation was prospectively performed in a group of 25 consecutive patients with PSS followed in an internal medicine department between June 1996 and December 1997 (Internal Medicine group). In addition, eleven patients with neurological complications of PSS were identified in the Neurological Department of the same institution during the same period (Neurological group). Results: In the Internal Medicine group, neurological complications were discovered in 10/25 (40%) patients. Peripheral nervous system involvement waspresent in 4/25 patients from the Internal Medicine group and in 10/11 patients from the Neurological group and consisted mainly of axonal sensorimotor/sensory polyneuropathy. A motor neuron syndrome was identified in two patients. CNS involvement occurred in 7/25 patients from the Internal Medicine group and in 4/11 patients from the Neurological group. Three patients had spinal cord involvement. Cognitive dysfunction was the most frequent finding (5/25 in the Internal Medicine group, 3/11 in the Neurological group) characterized either by subcortical or corticosubcortical dysfunction. Cognitive impairment was not attributed to mood disturbance and was not associated with specific laboratory or radiological abnormalities. Conclusion: Neurological complications of PSS are frequent since they were present in 40% (10/25) of patients in a consecutive series of patients from a department ofInternal Medicine. Although PNS involvement predominates, complications ofPSS affecting the brain or spinal cord are not rare, with subcortical dysfunction as the main finding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:51:26