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Titolo:
The effect of botulinum toxin injections to the calf muscles on freezing of gait in parkinsonism: a pilot study
Autore:
Giladi, N; Gurevich, T; Shabtai, H; Paleacu, D; Simon, ES;
Indirizzi:
Tel Aviv Med Ctr & Sch Med, Dept Neurol, Movement Disorders Unit, IL-64239Tel Aviv, Israel Tel Aviv Med Ctr & Sch Med Tel Aviv Israel IL-64239 4239Tel Aviv, Israel
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 7, volume: 248, anno: 2001,
pagine: 572 - 576
SICI:
0340-5354(200107)248:7<572:TEOBTI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE; MOTOR;
Keywords:
gait; freezing; freezing of gait; parkinsonism; botulinum toxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Giladi, N Tel Aviv Med Ctr & Sch Med, Dept Neurol, Movement Disorders Unit, 6 Weizman St, IL-64239 Tel Aviv, Israel Tel Aviv Med Ctr & Sch Med 6 Weizman St Tel Aviv Israel IL-64239
Citazione:
N. Giladi et al., "The effect of botulinum toxin injections to the calf muscles on freezing of gait in parkinsonism: a pilot study", J NEUROL, 248(7), 2001, pp. 572-576

Abstract

Background Freezing. of gait (FOG) is a common and very disabling parkinsonian symptom, which is poorly understood and responds unsatisfactorily to medical treatment. We recently reported a unique patient with Parkinson's disease (PD) who had significant alleviation of FOG shortly after she was injected with botulinum. toxin type A (BTX-A) for foot dystonia (Giladi et al.1997). Objective To assess the effect of BTX-A injections into the calf muscles of parkinsonian patients on FOG. Method BTX-A was injected in an openfashion into the calf muscles of 10 parkinsonian patients (age 55-75 years) with FOG as a predominant symptom. Response of FOG was assessed subjectively by the patient from worsening (-1) to marked improvement (+3). One patient was injected in a single blind fashion with saline or BTX-A after he had an initial good response. Results Seven patients reported different ratesof improvement of FOG severity in 15 out of 17 therapeutic sessions. Four patients (40%) reported marked improvement (+3) of FOG in 5 sessions. Two patients reported no effect in two sessions. The mean duration of improvement was 6 weeks. (range 1-12 weeks) with definite deterioration afterwards. The patient who was injected in a single blind fashion did not respond to saline injections but improved significantly with BTX-A treatment. Conclusions We observed a dear temporal relationship between BTX-A injections into the calf muscles of parkinsonian patients and improvement of FOG. A double blind placebo controlled prospective study is needed before any conclusions can be drawn about the role of BTX-A injection in FOG.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:18:01