Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Theiler's virus-infected L-selectin-deficient mice have decreased infiltration of CD8(+) T lymphocytes in central nervous system but clear the virus
Autore:
Zhang, XX; Brewer, L; Walcheck, B; Johnson, A; Pease, LR; Njenga, MK;
Indirizzi:
Univ Minnesota, Dept Vet Pathobiol, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Vet Pathobiol, St Paul, MN 55108 USA Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 unol, Rochester, MN 55905 USA
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 2, volume: 116, anno: 2001,
pagine: 178 - 187
SICI:
0165-5728(20010601)116:2<178:TVLMHD>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE HYPERSENSITIVITY; INDUCED DEMYELINATING DISEASE; CHORIOMENINGITIS VIRUS; CELL RESPONSE; IMMUNE-SYSTEM; ENCEPHALOMYELITIS; MIGRATION; EPITOPE; MOUSE; BETA-2-MICROGLOBULIN;
Keywords:
L-selectin; Theiler's virus; central nervous system; lymphocytes; demyelination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Njenga, MK Univ Minnesota, Dept Vet Pathobiol, 1971 Commonwealth Ave, St Paul, MN 55108 USA Univ Minnesota 1971 Commonwealth Ave St Paul MN USA 551088 USA
Citazione:
X.X. Zhang et al., "Theiler's virus-infected L-selectin-deficient mice have decreased infiltration of CD8(+) T lymphocytes in central nervous system but clear the virus", J NEUROIMM, 116(2), 2001, pp. 178-187

Abstract

Mice with targeted deletion of L-selectin gene (L-sel(-/-)) were used to investigate the role of adhesion molecule in immunologic responses followingvirus infection in the central nervous system (CNS). L-Sel(-/-) mice from a resistant H-2(b) genetic background and parental wild-type H-2(b) (C57BL/6) mice were infected with Theiler's murine encephalomyelitis virus (TMEV) intracerebrally and the kinetics of virus replication and infiltration of immune cells in the CNS determined. The levels of infectious TMEV, as measured by plaque assay at 3, 7, 14, and 28 days after infection were between 4 and 6 log(10) to PFU of virus per gram of CNS tissues at days 3 and 7 post-infection, and then decreased to undetectable levels by day 14 after infection in both strains of mice. The L-sel(-/-) mice had decreased numbers of CD8(+) T lymphocytes (17.72% +/- 2.4) infiltrating into the CNS at 7 days post-infection when compared to wild-type mice (31.02% +/- 7.5). In addition,the L-sel(-/-) mice had significantly lower levels of TMEV-specific serum IgG resulting in lower virus neutralizing activity of the serum when compared to wild-type mice. However, the L-sel(-/-) mice had 2.5-fold increase inB lymphocytes in the CNS (8.29% +/- 1.1) when compared to wild-type mice (3.2% +/- 0.4). Taken together, these data indicate that L-selectin plays a role in recruitment of B and CD8(+) T lymphocytes into the CNS following virus infection, which, however, did not affect the ability of the mice to clear TMEV infection. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 18:12:03