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Titolo:
Changes with aging in the modulation by neuropeptide Y of murine peritoneal macrophage functions
Autore:
De la Fuente, M; Del Rio, M; Medina, S;
Indirizzi:
Univ Complutense Madrid, Fac Biol, Dept Anim Physiol, Madrid, Spain Univ Complutense Madrid Madrid Spain , Dept Anim Physiol, Madrid, Spain
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 2, volume: 116, anno: 2001,
pagine: 156 - 167
SICI:
0165-5728(20010601)116:2<156:CWAITM>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIN-RELEASING PEPTIDE; SULFATED CHOLECYSTOKININ-OCTAPEPTIDE; VASOACTIVE-INTESTINAL-PEPTIDE; PROTEIN-KINASE-C; ADENYLATE-CYCLASE; PHAGOCYTIC FUNCTION; CYTOKINE PRODUCTION; ASCORBIC-ACID; RAT; CELLS;
Keywords:
aging; neuropeptide Y; macrophage functions; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M Univ Complutense, Fac Ciencias Biol, Dept Biol Anim FisiolAnim 2, Av Complutense S-N, E-28040 Madrid, Spain Univ Complutense Av Complutense S-N Madrid Spain E-28040
Citazione:
M. De la Fuente et al., "Changes with aging in the modulation by neuropeptide Y of murine peritoneal macrophage functions", J NEUROIMM, 116(2), 2001, pp. 156-167

Abstract

Some age-related changes in immune function may be due, at least in part, to a disturbance in the communication between the nervous and immune systems. In the present work, the effects in vitro of neuropeptide Y (NPY) (10(-13) to 10(-7) M) on different peritoneal macrophage functions (adherence to substrate, chemotaxis, phagocytosis, superoxide anion production, and the release of TNF alpha and IL-1 beta) have been studied on cells from young (12 +/- 2 weeks), adult (24 +/- 2 weeks), mature (50 +/- 2 weeks) and old (72+/- 2 weeks) BALB/c mice. The specificity of these actions was confirmed using two C-terminal fragments of NPY, and the intracellular messengers (protein kinase C and cAMP) involved in the action of the neuropeptide were also analyzed. The results show that the functions studied change with aging and that the effects of NPY on each function, which are carried out through specific receptors, as well as on intracellular pathway, differ depending on age, maintaining the immune functions at physiologically adequate levels in old animals. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:05:23