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Titolo:
Differential effects of neuropeptide Y (NPY) on leukocyte subsets in the blood: mobilization of B-1-like B-lymphocytes and activated monocytes
Autore:
Bedoui, S; Kuhlmann, S; Nave, H; Drube, J; Pabst, R; von Horsten, S;
Indirizzi:
Hannover Med Sch, Dept Funct & Appl Anat, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 nat, D-30625 Hannover, Germany
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1-2, volume: 117, anno: 2001,
pagine: 125 - 132
SICI:
0165-5728(20010702)117:1-2<125:DEONY(>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; MONOCLONAL-ANTIBODY; MOLECULAR MECHANISMS; IMMUNE-SYSTEM; T-CELLS; IN-VIVO; RAT; NORADRENALINE; COMPARTMENT; EXPRESSION;
Keywords:
neuropeptide Y (NPY); leukocyte subpopulations; NK-cells; CD5(+) CD11b(+) B-1 cells; activated monocytes; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: von Horsten, S Hannover Med Sch, Dept Funct & Appl Anat, OE 4120,Carl Neuberg Str 1, D-30625 Hannover, Germany Hannover Med Sch OE 4120,Carl Neuberg Str 1 Hannover Germany D-30625
Citazione:
S. Bedoui et al., "Differential effects of neuropeptide Y (NPY) on leukocyte subsets in the blood: mobilization of B-1-like B-lymphocytes and activated monocytes", J NEUROIMM, 117(1-2), 2001, pp. 125-132

Abstract

Sympathetic nervous system activation mobilizes leukocytes but it is unknown whether the concomitant neuropeptide Y (NPY)-release also alters blood leukocyte counts. Using chronic intravenous (i.v.) cannulation of freely moving rats and flow cytometry, time-, dose- and subset-specific effects of NPY on blood leukocytes were investigated 1-15 min after injection: High-doseNPY increases leukocytes numbers by preferentially mobilizing CD4(+) T-cells, activated NKR-P1A(+) monocytes and NK-cells. Low-dose NPY significantlydecreases B-lymphocyte and NK-cell numbers. Furthermore, NPY dose-dependently mobilizes a previously undetected IgM(low)CD5(+) CD11b(+) B-cell subpopulation in rats ("B1-like" B-lymphocytes). These data suggest a role for the sympathetic neurotransmitter NPY in neuroimmune alterations in vivo. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:30:24