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Titolo:
Vascular endothelial growth factor (VEGF) levels in peritoneal dialysis effluent
Autore:
Selgas, R; del Peso, G; Bajo, MA; Molina, S; Cirugeda, A; Sanchez-Tomero, JA; Castro, MJ; Castro, MA; Vara, F;
Indirizzi:
Hosp Univ La Princesa Madrid, Serv Nefrol, E-28006 Madrid, Spain Hosp UnivLa Princesa Madrid Madrid Spain E-28006 E-28006 Madrid, Spain La Paz Univ Hosp, Madrid, Spain La Paz Univ Hosp Madrid SpainLa Paz Univ Hosp, Madrid, Spain Univ Autonoma Madrid, Sch Med, Dept Biochem, Madrid, Spain Univ Autonoma Madrid Madrid Spain Sch Med, Dept Biochem, Madrid, Spain
Titolo Testata:
JOURNAL OF NEPHROLOGY
fascicolo: 4, volume: 14, anno: 2001,
pagine: 270 - 274
SICI:
1121-8428(200107/08)14:4<270:VEGF(L>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM; HUMAN KIDNEY; EXPRESSION; CELLS; LOCALIZATION; MACROPHAGES; FLUID;
Keywords:
long-term peritoneal dialysis; peritoneal solute transport; vascular endothelial growth factor (VEGF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Selgas, R Hosp Univ La Princesa Madrid, Serv Nefrol, Diego de Leon 62, E-28006 Madrid, Spain Hosp Univ La Princesa Madrid Diego de Leon 62 Madrid Spain E-28006
Citazione:
R. Selgas et al., "Vascular endothelial growth factor (VEGF) levels in peritoneal dialysis effluent", J NEPHROL, 14(4), 2001, pp. 270-274

Abstract

Background: Long term peritoneal dialysis (PD) patients who develop peritoneal ultrafiltration failure have an abnormally large number of capillariesand sclerotic changes in peritoneal biopsy. Peritoneal vascular endothelial growth factor (VEGF) production has been suggested to explain the higher levels in peritoneal effluent than in plasma. The high effluent VEGF levelshave been related to peritoneal changes consisting of increased permeability to small molecules. To further analyze the relationship between peritoneal neoangiogenesis induced by VEGF and peritoneal transport, we studied peritonea] effluent VEGF levels in active PD patients. Methods: VEGF levels were determined in serum and plasma, and in peritoneal effluent (PE) after 4, 8 and 15 h dwell times. Results: PE VEGF levels were 58.6 +/- 33.7 pg/mL, with a mean VEGF D/P ratio of 0.45 +/- 0.29 (range 0.06-0.93). In low-transport patients (n = 7) this ratio did not differ from high-average ones (n=5) (0.48 +/- 0.3 and 0.41+/- 0.1, NS). In multivariate analysis, the VEGF D/P ratio showed no correlation with the independent variables included in this study. VEGF levels were higher in 15 h than in 8 h effluent; so the VEGF D/P ratios were higheras well. Regression analysis showed a direct correlation between PEVEGF levels and dwell time (r: 0.57, p = 0.03), but not between VEGF D/P ratio anddwell time. PEVEGF levels directly correlated with effluent protein content. Regression analysis showed no correlation between PEVEGF levels and age,time on PD, days of peritonitis, urea and creatinine-mass transfer coefficients, ultrafiltration capacity, and accumulated glucose dose. Multivariateregression analysis showed correlation only between PEVEGF levels and dwell time, but not with the other independent variables. Conclusions: This study confirms that VEGF is present in fresh PE from PD patients at levels that suggest local production and filtration from plasma. Peritoneal effluent VEGF levels are not significantly associated with peritoneal functional parameters and background, and seem to be influenced by ultrafiltration in a dilution process. We believe that the role of VEGF in peritoneal pathophysiology is part of a complex relationship involving multiple peritoneal structures and other growth factors, including local counteracting factors for VEGF that regulate neoangiogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:04:34