Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The plasminogen activator inhibitor 1 4G/5G polymorphism is not associatedwith longevity: a study in octogenarians
Autore:
Lottermoser, K; Dusing, R; Ervens, P; Koch, B; Bruning, T; Sachinidis, A; Vetter, H; Ko, Y;
Indirizzi:
Univ Bonn, Med Poliklin, D-53111 Bonn, Germany Univ Bonn Bonn Germany D-53111 Bonn, Med Poliklin, D-53111 Bonn, Germany
Titolo Testata:
JOURNAL OF MOLECULAR MEDICINE-JMM
fascicolo: 5-6, volume: 79, anno: 2001,
pagine: 289 - 293
SICI:
0946-2716(200106)79:5-6<289:TPAI14>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; MYOCARDIAL-INFARCTION; GENE POLYMORPHISM; PAI-1 ACTIVITY; PLASMA-LEVELS; RISK FACTOR; PROMOTER; THROMBOSIS; ATHEROSCLEROSIS; POPULATION;
Keywords:
plasminogen activator inhibitor 1; 4G/5G polymorphism; longevity; light-cycler;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Dusing, R Univ Bonn, Med Poliklin, Wilhelmstr 35-37, D-53111 Bonn, GermanyUniv Bonn Wilhelmstr 35-37 Bonn Germany D-53111 1 Bonn, Germany
Citazione:
K. Lottermoser et al., "The plasminogen activator inhibitor 1 4G/5G polymorphism is not associatedwith longevity: a study in octogenarians", J MOL MED-J, 79(5-6), 2001, pp. 289-293

Abstract

Accumulating evidence suggests that plasma levels of the plasminogen activator inhibitor 1 (PAI-1) may modulate the risk of coronary artery disease. The regulation of PAI-1 levels underlies not only environmental but also genetic influences. The 4G/5G polymorphism of the PAI-1 gene has recently gained additional relevance as a possible cardiovascular risk factor, as the 4G allele may be associated with enhanced expression of the PAI-1 gene. Thisretrospective cohort study examined the effect of the PAI-1 4G/5G genotypeon longevity among 205 subjects aged 80 years and older. Such studies in larger cohorts have recently become available along with new methods for therapid and easy determination of gene polymorphisms. We utilized a light-cycler assisted method which is a fast and flexible method of analyzing the PAI-1 4G/5G polymorphism on the gene level. In these 205 persons the 4G/5G allele was found in 96 persons (47%), the 4G/4G variant in 62 (30%), and the5G/5G allele in 47 (23%). These data are similar to the allele distribution described in other large cohorts not restricted to old age. Thus the results of this study are not suggestive of an important contribution of the PAI-1 genotype on total mortality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:18:53