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Titolo:
Serum values of proinflammatory cytokines are inversely correlated with serum leptin levels in patients with advanced stage cancer at different sites
Autore:
Mantovani, G; Maccio, A; Madeddu, C; Mura, L; Massa, E; Mudu, MC; Mulas, C; Lusso, MR; Gramignano, G; Piras, MB;
Indirizzi:
Univ Cagliari, Policlin Univ, Dept Med Oncol, I-09042 Cagliari, Italy UnivCagliari Cagliari Italy I-09042 Med Oncol, I-09042 Cagliari, Italy Sirai Hosp, Div Obstet & Gynecol, Carbonia, Italy Sirai Hosp Carbonia Italy i Hosp, Div Obstet & Gynecol, Carbonia, Italy Univ Cagliari, Dept Biosyst Appl Sci, Sect Human Physiol, I-09042 Cagliari, Italy Univ Cagliari Cagliari Italy I-09042 an Physiol, I-09042 Cagliari, Italy
Titolo Testata:
JOURNAL OF MOLECULAR MEDICINE-JMM
fascicolo: 7, volume: 79, anno: 2001,
pagine: 406 - 414
SICI:
0946-2716(200107)79:7<406:SVOPCA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; OBESE GENE-PRODUCT; NEUROPEPTIDE-Y; BODY-WEIGHT; MEDROXYPROGESTERONE ACETATE; MEGESTROL-ACETATE; OB/OB MICE; IN-VITRO; CACHEXIA; EXPRESSION;
Keywords:
leptin; proinflammatory cytokines; cancer patients; cancer-related anorexia/cachexia; body mass index;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Mantovani, G Univ Cagliari, Policlin Univ, Dept Med Oncol, I-09042 Cagliari, Italy Univ Cagliari Cagliari Italy I-09042 -09042 Cagliari, Italy
Citazione:
G. Mantovani et al., "Serum values of proinflammatory cytokines are inversely correlated with serum leptin levels in patients with advanced stage cancer at different sites", J MOL MED-J, 79(7), 2001, pp. 406-414

Abstract

Leptin is a recently identified hormone produced by the adipocyte ob gene which acts as a negative feedback signal critical to the normal control of food intake and body weight. A number of proinflammatory cytokines, such asinterleukin 6, tumor necrosis factor alpha, and interferon gamma, have been proposed as mediators of cancer cachexia; these data suggest that abnormalities in leptin production/release or in its feedback mechanism play a role in cancer patients. We therefore studied the relationship between serum leptin and serum cytokines interleukin 6 and tumor necrosis factor alpha levels in advanced-stage cancer patients. Twenty-nine advanced stage cancer patients (all but one stage IV) with tumors at various sites were included inthe study. A direct correlation between body mass index and serum leptin levels was found both in cancer patients and in healthy individuals. The serum levels of interleukin 6 were significantly higher in cancer patients than in healthy individuals. In cancer patients an inverse correlation was found between serum levels of leptin and proinflammatory cytokines. There was an inverse correlation between the Eastern Cooperative Oncology Group performance status scale and serum levels of leptin. Regarding survival, patients with very high ser-um levels of proinflammatory cytokines and very low levels of leptin had very short survival. Although obtained in a cancer patient population not overtly cachectic, our results provide further evidence that a simple dysregulation of leptin production and/or release cannot be involved in cancer-associated pathophysiological changes leading to cachexia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:04:04