Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Alterations in the expression of interleukin-2R subunits by activated T cells from elderly humans are uncoupled from aberrancies in G(1)/S progression
Autore:
Ginn-Pease, ME; Whisler, RL;
Indirizzi:
Ohio State Univ, William H Davis Med Res Ctr, Dept Med Biochem, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Med Biochem, Columbus, OH 43210 USA Ohio State Univ, William H Davis Med Res Ctr, Dept Internal Med, Columbus,OH 43210 USA Ohio State Univ Columbus OH USA 43210 Internal Med, Columbus,OH 43210 USA
Titolo Testata:
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
fascicolo: 7, volume: 21, anno: 2001,
pagine: 515 - 521
SICI:
1079-9907(200107)21:7<515:AITEOI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; PROTEIN-TYROSINE KINASES; CYTOKINE PRODUCTION; RECEPTOR EXPRESSION; AGED HUMANS; IL-2; SUBSETS; PROLIFERATION; INDIVIDUALS; LYMPHOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Whisler, RL Ohio State Univ, William H Davis Med Res Ctr, Dept Med Biochem, 480 W 9th Ave, Columbus, OH 43210 USA Ohio State Univ 480 W 9th Ave Columbus OH USA 43210 43210 USA
Citazione:
M.E. Ginn-Pease e R.L. Whisler, "Alterations in the expression of interleukin-2R subunits by activated T cells from elderly humans are uncoupled from aberrancies in G(1)/S progression", J INTERF CY, 21(7), 2001, pp. 515-521

Abstract

Activated T cells from elderly humans are known to often display a declinein interleukin-2 (IL-2) production. However, the possible effects of agingon the expression of IL-2 receptor (IL-2R) subunits by human T cells are more controversial and less well characterized. In the present investigation, the surface expression of IL-2R alpha, IL-2R beta, and IL-2R gamma subunits on resting and activated T cells from 15 sets of elderly and young humans was evaluated. The results showed no significant differences in the average expression of IL-2R alpha, IL-2R beta, and IL-2R gamma on resting T cells from elderly and young subjects, with values of 10% or less. Similarly, no significant differences were found in the mean levels of IL-2R alpha, IL-2R beta, and IL-2R gamma on T cells from elderly and young subjects stimulated with anti-Ig cross-linked anti-CD3 (monoclonal antibody [mAb] OKT3), phorbol myristate acetate (PMA), anti-CD3 and PMA, or 1% phytohemagglutinin (PHA) plus PMA. Analyses of the expression of IL-2R on activated T cells from elderly people revealed a marked heterogeneity in IL-2R levels irrespective of the stimuli. Other experiments showed that the age-related alterations in surface expression of IL-2R alpha were not correlated to changes in the release of soluble IL-2R alpha. Age-related changes in IL-2R expression on activated T cells from individual donors were not coupled to the ability of the T cells to undergo G(1)/S progression. Collectively, these observations suggest that activated T cells from elderly people exhibit substantial heterogeneity in the expression of IL-2R subunits and that alterations in IL-2R expression may be distinct from intrinsic defects in G(1)/S progression and proliferative responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:02:50