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Titolo:
Association analysis of polymorphisms in the prepronociceptin gene and schizophrenia
Autore:
Imai, K; Harada, S; Kawanishi, Y; Tachikawa, H; Okubo, T; Suzuki, T;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Dept Psychiat, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan
Titolo Testata:
JOURNAL OF HUMAN GENETICS
fascicolo: 8, volume: 46, anno: 2001,
pagine: 442 - 447
SICI:
1434-5161(2001)46:8<442:AAOPIT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOCICEPTIN/ORPHANIN FQ PRECURSOR; ORPHANIN-FQ; TISSUE DISTRIBUTION; MICE LACKING; RECEPTOR; LOCALIZATION; NEUROPEPTIDE; NOCISTATIN; PEPTIDE;
Keywords:
prepronociceptin; polymorphism; association analysis; schizophrenia; continuous course;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Imai, K Univ Tsukuba, Inst Clin Med, Dept Psychiat, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba 1-1-1 Tennoudai Tsukuba Ibaraki Japan 3058575 , Japan
Citazione:
K. Imai et al., "Association analysis of polymorphisms in the prepronociceptin gene and schizophrenia", J HUM GENET, 46(8), 2001, pp. 442-447

Abstract

The human prepronociceptin (ppNoc) gene is located on chromosome 8p21, andseveral linkage studies have suggested that the susceptibility locus for schizophrenia is present in this chromosomal region. We investigated geneticvariations in the promoter and coding regions of the ppNoc gene to determine if there may be an association between naturally occurring mutations andthe manifestation of schizophrenia. Association analyses for the variations found were conducted between 87 unrelated schizophrenic patients and 100 healthy controls. Polymorphisms were found at both the -503 locus (G/A) in the promoter region and the 353 locus (Ala118Gly) in exon 3. Additionally, rare variants were identified at the -261 locus (A/G) in the promoter region, the 515 locus (Gln172Arg) in exon 3, and the 561 locus (G/A) in the untranslated region of exon 3. A significant difference was observed in allele frequency at the 353 locus between controls and patients with continuous-course schizophrenia (P = 0.0237), and between patients with and without prominent negative symptoms (P = 0.0201). However, neither difference was significant after Bonferroni correction. In addition, there were no significant differences in genotype and allele frequencies at either the -503 or 353 locus between the control group and patients with schizophrenia. These results suggest that ppNoc gene polymorphisms have no association with schizophrenia.

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Documento generato il 22/01/20 alle ore 21:40:18