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Titolo:
Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice
Autore:
Grover, JK; Vats, V; Rathi, SS; Dawar, R;
Indirizzi:
All India Inst Med Sci, Dept Pharmacol, New Delhi 110049, India All India Inst Med Sci New Delhi India 110049 l, New Delhi 110049, India St Boniface Inst Cardiovasc Sci, Winnipeg, MB, Canada St Boniface Inst Cardiovasc Sci Winnipeg MB Canada Winnipeg, MB, Canada All India Inst Med Sci, Dept Pathol, New Delhi 110049, India All India Inst Med Sci New Delhi India 110049 l, New Delhi 110049, India
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 3, volume: 76, anno: 2001,
pagine: 233 - 238
SICI:
0378-8741(200108)76:3<233:TIAPAP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALBUMIN EXCRETION; RATS; NEPHROPATHY; PREVALENCE; MEDICINE; MELLITUS;
Keywords:
Momordica charantia; Eugenia jambolana; Tinospora cordifolia; Mucuna pruriens; experimental diabetes; diabetic nephropathy; Streptozotocin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Grover, JK All India Inst Med Sci, Dept Pharmacol, New Delhi 110049, IndiaAll India Inst Med Sci New Delhi India 110049 i 110049, India
Citazione:
J.K. Grover et al., "Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice", J ETHNOPHAR, 76(3), 2001, pp. 233-238

Abstract

The purpose of the study was to investigate the effects of daily oral feeding Momordica charantia (MC) (200 mg/kg), Eugenia jambolana (EJ) (200 mg/kg), Mucuna pruriens (MP) (200 mg/kg) and Tinospora cordifolia (TC) extracts for 40 days on blood glucose concentrations and kidney functions in streptozotocin (STZ)-diabetic rats. Plasma glucose levels, body weight, urine volume and urinary albumin levels were monitored on every 10th day over a 40-day period while plasma creatinine levels were assessed at the beginning and end of experiment. Renal hypertrophy was assessed as the ratio between the kidney weight and total body weight. Plasma glucose concentrations in STZ-diabetic mice were reduced by the administration of extracts of MC, EJ, TC and NIP by 24.4, 20.84, 7.45 and 9.07%, respectively (P < 0.005 for MC, EJ, NIP and P < 0.05 for TC). Urine volume was significantly higher (P < 0.005)in diabetic controls and NIC, EJ, NIP and TC treatment prevented polyuria (P < 0.001, 0.0001, 0.01 and 0.001, respectively). After 10 days of STZ administration urinary albumin levels (UAE) were over 6 fold higher in diabetic controls as compared to normal controls. Treatment with NIC, EJ, NIP and TC significantly prevented the rise in UAE levels from day 0 to 40 in comparison to diabetic controls (P < 0.0001, 0.0001, 0.05, 0.05, respectively). Renal hypertrophy was significantly higher in diabetic controls as comparedto non-diabetic controls. NIC and EJ partially but significantly (P < 0.05) prevented renal hypertrophy as compared to diabetic controls. TC and NIP failed to modify renal hypertrophy. Results indicate that these plant drugsshould be studied further. <(c)> 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 09:40:07