Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Localization of two high-threshold potassium channel subunits in the rat central auditory system
Autore:
Li, W; Kaczmarek, LK; Perney, TM;
Indirizzi:
Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA RutgersState Univ Newark NJ USA 07102 hav Neurosci, Newark, NJ 07102 USA Rutgers State Univ, Ctr Human Genet, Nelson Labs, Newark, NJ 07102 USA Rutgers State Univ Newark NJ USA 07102 Nelson Labs, Newark, NJ 07102 USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA Yale Univ NewHaven CT USA 06520 Dept Pharmacol, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 r & Mol Physiol, New Haven, CT 06520 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 2, volume: 437, anno: 2001,
pagine: 196 - 218
SICI:
0021-9967(20010820)437:2<196:LOTHPC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; BUSHY CELL AXONS; HETEROMULTIMERIC K+ CHANNELS; COCHLEAR NUCLEUS NEURONS; GLOBUS-PALLIDUS NEURONS; MEDIAL GENICULATE-BODY; LATERAL SUPERIOR OLIVE; CAT TRAPEZOID BODY; VITRO BRAIN SLICE; INFERIOR COLLICULUS;
Keywords:
cochlear nucleus; superior olivary complex; nuclei of the lateral lemniscus; inferior colliculus; medial geniculate body;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Perney, TM Rutgers State Univ, Ctr Mol & Behav Neurosci, 197 Univ Ave, Newark, NJ 07102 USA Rutgers State Univ 197 Univ Ave Newark NJ USA 07102 J 07102 USA
Citazione:
W. Li et al., "Localization of two high-threshold potassium channel subunits in the rat central auditory system", J COMP NEUR, 437(2), 2001, pp. 196-218

Abstract

The firing pattern of auditory neurons is determined in part by the type of voltage-sensitive potassium channels expressed. The expression patterns for two high-threshold potassium channels, Kv3.1 and Kv3.3, that differ in inactivation properties were examined in the rat auditory system. The positive activation voltage and rapid deactivation kinetics of these channels provide rapid repolarization. of action potentials with little effect on action potential threshold. In situ hybridization experiments showed that Kv3.3 mRNA was highly expressed in most auditory neurons in the rat brainstem, whereas Kv3.1 was expressed in a more limited population of auditory neurons. Notably, Kv3.1 mRNA was not expressed in neurons of the medial and lateralsuperior olive and a subpopulation of neurons in the ventral nucleus of the lateral lemniscus. These results suggest that Kv3.3 channels may be the dominant Kv3 subfamily member expressed in brainstem. auditory neurons and that, in some auditory neurons, Kv3.1 and Kv3.3 may coassemble to form functional channels. The localization of Kv3.1 protein was examined immunohistochemically. The distribution of stained somata and neuropil varied across auditory nuclei and correlated with the distribution of Kv3.1 mRNA-expressingneurons and their terminal arborizations, respectively. The intensity of Kv3.1 immunoreactivity varied across the tonotopic map in the medial nucleusof the trapezoid body with neurons responding best to high-frequency tonesmost intensely labeled. Thus, auditory neurons may vary the types and amount of K+ channel expression in response to synaptic input to subtly tune their firing properties. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:52:22