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Titolo:
Morphology, electrophysiology, and calbindin immunoreactivity of myentericneurons in the guinea pig distal colon
Autore:
Tamura, K; Ito, H; Wade, PR;
Indirizzi:
Tokai Univ, Dept Physiol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Yamanouchi Pharmaceut Co Ltd, Inst Drug Discoveries, Tsukuba, Ibaraki 3058585, Japan Yamanouchi Pharmaceut Co Ltd Tsukuba Ibaraki Japan 3058585 3058585, Japan Columbia Univ Coll Phys & Surg, Dept Anat & Cell Biol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 4, volume: 437, anno: 2001,
pagine: 423 - 437
SICI:
0021-9967(20010903)437:4<423:MEACIO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE-INTESTINAL-PEPTIDE; NEUROCHEMICAL CLASSIFICATION; PLEXUS NEURONS; COUNT NEURONS; AH-NEURONS; PROJECTIONS; ILEUM; BIOCYTIN; MOTILITY; BEHAVIOR;
Keywords:
enteric nervous system; intracellular recording; N-(2-aminoethyl) biotinamide; camera lucida; calbindin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Tamura, K Kanagawa Dent Coll, Dept Physiol, Inaoka Cho 82, Yokosuka, Kanagawa 2388580, Japan Kanagawa Dent Coll Inaoka Cho 82 Yokosuka Kanagawa Japan2388580
Citazione:
K. Tamura et al., "Morphology, electrophysiology, and calbindin immunoreactivity of myentericneurons in the guinea pig distal colon", J COMP NEUR, 437(4), 2001, pp. 423-437

Abstract

The morphological and physiological characteristics of myenteric neurons in the guinea pig distal colon were determined using Lucifer yellow- or N-(2-aminoethyl) biotinamide-containing microelectrodes and intracellular recording and staining methods. The neurons in this study (n = 204) were classified on the basis of the shapes of their cell bodies and short processes or dendrites and the number of long processes or axons as Dogiel type I (n = 75 neurons; 36.8%), filamentous (n = 31 neurons; 15.2%), Dogiel type II (n =38 neurons; 18.6%), and unclassified (n = 60 neurons; 29.4%). All Dogiel type II neurons had action potentials followed by an after-spike hyperpolarization (AH), and most of them (84%) had large, smooth sonata and filamentous, short processes in addition to multiple, long processes or axons. Most of Dogiel type I, filamentous, and unclassified neurons (98%) had a single, long process, but four Dogiel type I neurons and one unclassified neuron had two long processes terminating as varicosities within other ganglia or onthe surface of longitudinal muscle. The projections of monoaxonal neurons were distributed equally between oral and aboral directions, and most of them received fast excitatory postsynaptic potentials (EPSPs). All of the Dogiel type II neurons and seven Dogiel type I neurons were positive for calbindin immunoreactivity, but three filamentous neurons received fEPSPs, had spikes followed by AH, and were negative for calbindin. The presence of calbindin-immunoreactive(-IR) neurons was quite variable among the ganglia. These results confirm that neither the presence of calbindin immunoreactivity nor the absence of fEPSPs can be used as a predictor of cellular morphologyor electrophysiological properties of myenteric neurons in the distal colon. J. Comp. Neurol. 437:423-437, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:25:44