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Titolo:
Distribution of androgen and estrogen receptor mRNA in the brain and reproductive tissues of the leopard gecko, Eublepharis macularius
Autore:
Rhen, T; Crews, D;
Indirizzi:
NIEHS, Lab Signal Transduct, NIH, Res Triangle Pk, NC 27709 USA NIEHS ResTriangle Pk NC USA 27709 ct, NIH, Res Triangle Pk, NC 27709 USA Univ Texas, Sch Biol Sci, Sect Integrat Biol, Austin, TX 78712 USA Univ Texas Austin TX USA 78712 , Sect Integrat Biol, Austin, TX 78712 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 4, volume: 437, anno: 2001,
pagine: 385 - 397
SICI:
0021-9967(20010903)437:4<385:DOAAER>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT SEX DETERMINATION; SITU HYBRIDIZATION ANALYSIS; LIZARD PODARCIS-HISPANICA; SNAKE THAMNOPHIS-SIRTALIS; FEMALE WHIPTAIL LIZARDS; CNEMIDOPHORUS-UNIPARENS; PHEROMONAL DISCRIMINATION; EFFERENT CONNECTIONS; AGGRESSIVE-BEHAVIOR; OLFACTORY BULBS;
Keywords:
androgens; estrogens; hypothalamus; sex behavior; temperature-dependent sex determination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Rhen, T NIEHS, Lab Signal Transduct, NIH, Res Triangle Pk, NC 27709 USA NIEHS Res Triangle Pk NC USA 27709 Res Triangle Pk, NC 27709 USA
Citazione:
T. Rhen e D. Crews, "Distribution of androgen and estrogen receptor mRNA in the brain and reproductive tissues of the leopard gecko, Eublepharis macularius", J COMP NEUR, 437(4), 2001, pp. 385-397

Abstract

Incubation temperature during embryonic development determines gonadal sexin the leopard gecko, Eublepharis macularius. In addition, both incubationtemperature and gonadal sex influence behavioral responses to androgen andestrogen treatments in adulthood. Although these findings suggest that temperature and sex steroids act upon a common neural substrate to influence behavior, it is unclear where temperature and hormone effects are integrated. To bogie to address this question, we identified areas of the leopard gecko brain that express androgen receptor {AR) and estrogen receptor {ER) mRNA. We gonadectomized adult female and male geckos from an incubation temperature that produces a female-biased sex ratio and another temperature that produces a male-biased sex ratio. Females and males from both temperatures were then treated with equivalent levels of various sex steroids. Region-specific patterns of AR mRNA expression and ER mRNA expression were observed upon hybridization of radiolabeled (S-35) cRNA probes to thin sections of reproductive tissues (male hemipenes and female oviduct) and brain. Labelingfor AR mRNA was very intense in the epithelium, but not within the body, of the male hemipenes. In contrast, expression of ER mRNA was prominent in most of the oviduct but not in the luminal epithelium. Within the brain, labeling for AR mRNA was conspicuous in the anterior olfactory nucleus, the lateral septum, the medial preoptic area, the periventricular preoptic area, the external nucleus of the amygdala, the anterior hypothalamus, the ventromedial hypothalamus, the premammillary nucleus, and the caudal portion of the periventricular nucleus of the hypothalamus. Expression of ER mRNA was sparse in the septum and was prominent in the ventromedial hypothalamus, thecaudal portion of the periventricular nucleus of the hypothalamus, and a group of cells near the torus semicircularis. Many of these brain regions have been implicated in the regulation of hormone-dependent, sex-typical reproductive and agonistic behaviors in other vertebrates. Consequently, these nuclei are likely to control such behaviors in the leopard gecko and also are candidate neural substrates for mediating temperature effects on behavior. J. Comp. Neurol. 437:385-397, 2001 (C). 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:45:38