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Titolo:
Comparison of breast magnetic resonance imaging, mammography, and ultrasound for surveillance of women at high risk for hereditary breast cancer
Autore:
Warner, E; Plewes, DB; Shumak, RS; Catzavelos, GC; Di Prospero, LS; Yaffe, MJ; Goel, V; Ramsay, E; Chart, PL; Cole, DEC; Taylor, GA; Cutrara, M; Samuels, TH; Murphy, JP; Murphy, JM; Narod, SA;
Indirizzi:
Sunnybrook & Womens Coll Hlth Sci Ctr, Div Med, Dept Med Biophys, Toronto,ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr Toronto ON Canada ronto,ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr, Div Prevent Oncol, Dept Med Biophys, Toronto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr Toronto ON Canada onto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr, Div Prevent Oncol, Dept Med Imaging, Toronto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr Toronto ON Canada onto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr, Div Med, Dept Med Imaging, Toronto,ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr Toronto ON Canada ronto,ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr, Div Med, Dept Pathol, Toronto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr Toronto ON Canada onto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr, Div Prevent Oncol, Dept Pathol, Toronto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr Toronto ON Canada onto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr, Div Prevent Oncol, Dept Surg, Toronto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr Toronto ON Canada onto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr, Div Med, Dept Surg, Toronto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr Toronto ON Canada onto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr, Ctr Res Womens Hlth, Toronto, ON, Canada Sunnybrook & Womens Coll Hlth Sci Ctr Toronto ON Canada onto, ON, Canada Toronto Hosp, Dept Clin Biochem, Toronto, ON, Canada Toronto Hosp TorontoON Canada p, Dept Clin Biochem, Toronto, ON, Canada Univ Toronto, Dept Hlth Adm, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 h Adm, Toronto, ON M5S 1A1, Canada
Titolo Testata:
JOURNAL OF CLINICAL ONCOLOGY
fascicolo: 15, volume: 19, anno: 2001,
pagine: 3524 - 3531
SICI:
0732-183X(20010801)19:15<3524:COBMRI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATHOLOGICAL CORRELATION; GADOLINIUM-DTPA; GD-DTPA; BRCA1; LESIONS; EFFICACY; DENSITY; GENE; EXPERIENCE; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Warner, E Toronto Sunnybrook Reg Canc Ctr, Div Med Oncol, 2075 Bayview Ave, Toronto,ON M4N 3M5, Canada Toronto Sunnybrook Reg Canc Ctr 2075 Bayview Ave Toronto ON Canada M4N 3M5
Citazione:
E. Warner et al., "Comparison of breast magnetic resonance imaging, mammography, and ultrasound for surveillance of women at high risk for hereditary breast cancer", J CL ONCOL, 19(15), 2001, pp. 3524-3531

Abstract

Purpose: Recommended surveillance for BRCA1 and BRCA2 mutation carriers includes regular mammography and clinical breast examination, although the effectiveness of these screening techniques in mutation carriers has not beenestablished. The purpose of the present study was to compare breast magnetic resonance imaging (MRI) with ultrasound, mammography, and physical examination in women at high risk for hereditary breast cancer. Patients and Methods: A total of 196 women, aged 26 to 59 years, with proven BRCA1 or BRCA2 mutations or strong family histories of breast or ovariancancer underwent mammography, ultrasound, MRI, and clinical breast examination on a single day. A biopsy was performed when any of the four investigations was judged to be suspicious for malignancy. Results: Six invasive breast cancers and one noninvasive breast cancer were detected among the 196 high-risk women. Five of the invasive cancers occurred in mutation carriers, and the sixth occurred in a woman with a previous history of breast cancer. The prevalence of invasive or noninvasive breast cancer in the 96 mutation carriers was 6.2%. All six invasive cancers were detected by MRI, all were 1.0 cm or less in diameter, and all were node-negative. In contrast, only three invasive cancers were detected by ultrasound, two by mammography, and two by physical examination. The addition of MRI to the more commonly available triad of mammography, ultrasound, and breast examination identified two additional invasive breast cancers that wouldotherwise have been missed. Conclusion: Breast MRI may be superior to mammography and ultrasound for the screening of women at high risk for hereditary breast cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:23:10