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Titolo:
T cell repertoire in primary biliary cirrhosis: A common T cell clone and repertoire change after treatment
Autore:
Okamoto, R; Yamamoto, K; Yabushita, K; Okano, N; Shimada, N; Matsumura, S; Mizuno, M; Higashi, T; Tsuji, T;
Indirizzi:
Okayama Univ, Sch Med, Dept Internal Med 1, Okayama 700, Japan Okayama Univ Okayama Japan 700 , Dept Internal Med 1, Okayama 700, Japan
Titolo Testata:
JOURNAL OF CLINICAL IMMUNOLOGY
fascicolo: 4, volume: 21, anno: 2001,
pagine: 278 - 285
SICI:
0271-9142(200107)21:4<278:TCRIPB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
URSODEOXYCHOLIC-ACID THERAPY; PYRUVATE-DEHYDROGENASE COMPLEX; RANDOMIZED CONTROLLED TRIALS; RHEUMATOID-ARTHRITIS; CLONOTYPES; LIVER; PREDNISOLONE; ACCUMULATION; LYMPHOCYTES; AUTOIMMUNE;
Keywords:
primary biliary cirrhosis; T cell repertoire; T cell receptor; prednisolone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Yamamoto, K Okayama Univ, Sch Med, Dept Internal Med 1, 2-5-1 Shikata Cho,Okayama 700, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 700 a 700, Japan
Citazione:
R. Okamoto et al., "T cell repertoire in primary biliary cirrhosis: A common T cell clone and repertoire change after treatment", J CLIN IMM, 21(4), 2001, pp. 278-285

Abstract

T cell repertoire was analyzed in three early-stage primary biliary cirrhosis (PBC) patients, using reverse transcription-polymerase chain reaction and single-strand conformation polymorphism. Multiple expanded clones were demonstrated in livers and peripheral blood lymphocytes (PBL) of all three patients. Comparison of the repertoire of different parts of the liver demonstrated the presence of common clones in various V beta families. Comparison of the repertoire between the liver and PBL demonstrated that both CD4 and CD8 T cell clones were expanded. Sequence analysis of complementarity determining region 3 of the expanded clones revealed that relatively conservedamino acids were utilized in each patient and that an identical CD4 T cellclone having V beta 16 was present in all three patients. The number of expanded T cell clones in PBL decreased markedly after the treatment with prednisolone. These results suggest that common T cell clones may play a pathogenic role in PBC.

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Documento generato il 30/11/20 alle ore 07:19:14