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Titolo:
Dietary probiotic supplementation enhances natural killer cell activity inthe elderly: An investigation of age-related immunological changes
Autore:
Gill, HS; Rutherfurd, KJ; Cross, ML;
Indirizzi:
Massey Univ, Inst Food Nutr & Human Hlth, Milk & Hlth Res Ctr, Palmerston North, New Zealand Massey Univ Palmerston North New Zealand Palmerston North, New Zealand
Titolo Testata:
JOURNAL OF CLINICAL IMMUNOLOGY
fascicolo: 4, volume: 21, anno: 2001,
pagine: 264 - 271
SICI:
0271-9142(200107)21:4<264:DPSENK>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRACE-ELEMENT SUPPLEMENTATION; LACTOBACILLUS-CASEI; IMMUNE-RESPONSES; PERIPHERAL-BLOOD; NK-CELLS; BACTERIA; INTERLEUKIN-12; STIMULATION; NUTRITION; VITAMIN;
Keywords:
probiotics; natural killer cells; tumoricidal activity; immunosenescence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Gill, HS Massey Univ, Inst Food Nutr & Human Hlth, Milk & Hlth Res Ctr, Palmerston North, New Zealand Massey Univ Palmerston North New Zealand on North, New Zealand
Citazione:
H.S. Gill et al., "Dietary probiotic supplementation enhances natural killer cell activity inthe elderly: An investigation of age-related immunological changes", J CLIN IMM, 21(4), 2001, pp. 264-271

Abstract

Many elderly subjects are at increased risk of infectious and noninfectious diseases due to an age-related decline in lymphoid cell activity (immunosenescence). Noninvasive means of enhancing cellular immunity are therefore desirable in the elderly. Previous reports have suggested that dietary supplementation could represent an effective means of enhancing the activity ofcirculating natural killer (NK) cells in the elderly. In the present study, we have conducted a pre-post intervention trial to determine the impact of dietary supplementation with probiotic lactic acid bacteria (LAB) on peripheral blood NK cell activity in healthy elderly subjects. Twenty-seven volunteers consumed low-fat/low-lactose milk supplemented with known immunostimulatory LAB strains (Lactobacillus rhamnosus HN001 or Bifidobacterium lactis HN019) for a period of 3 weeks. A dietary run-in of milk alone was shownto have no significant effect on NK cells. Irt contrast, the proportion ofCD56-positive lymphocytes in peripheral circulation was higher following consumption of either LAB strain, and ex vivo PBMC tumoricidal activity against K562 cells was also increased. Supplementation with HN001 or HN019 increased tumoricidal activity by an average of 101 and 62%, respectively; these increases were significantly correlated with age, with subjects older than 70 years experiencing significantly greater improvements than those under70 years. These results demonstrate that dietary consumption of probiotic LAB in a milk-based diet may offer benefit to elderly consumers to combat some of the deleterious effects of immunosenescence on cellular immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:46:30