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Titolo:
Flp1, a fission yeast orthologue of the S-cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis
Autore:
Cueille, N; Salimova, E; Esteban, V; Blanco, M; Moreno, S; Bueno, A; Simanis, V;
Indirizzi:
Swiss Inst Expt Canc Res, ISREC, Cell Cycle Control Lab, CH-1066 Epalinges, Switzerland Swiss Inst Expt Canc Res Epalinges Switzerland CH-1066 nges, Switzerland Univ Salamanca, CSIC, Inst Microbiol Bioquim, Edificio Dept, Salamanca 37007, Spain Univ Salamanca Salamanca Spain 37007 ificio Dept, Salamanca 37007, Spain
Titolo Testata:
JOURNAL OF CELL SCIENCE
fascicolo: 14, volume: 114, anno: 2001,
pagine: 2649 - 2664
SICI:
0021-9533(200107)114:14<2649:FAFYOO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINDLE POLE BODY; SPECIFICITY PROTEIN PHOSPHATASE; WEE1 TYROSINE KINASE; CELL-DIVISION CYCLE; SCHIZOSACCHAROMYCES-POMBE; SEPTUM FORMATION; SACCHAROMYCES-CEREVISIAE; MITOTIC INDUCER; REGULATORY NETWORK; DNA-REPLICATION;
Keywords:
mitosis; cytokinesis; phosphatase; mitotic exit;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
80
Recensione:
Indirizzi per estratti:
Indirizzo: Simanis, V Swiss Inst Expt Canc Res, ISREC, Cell Cycle Control Lab, CheminBoveresses155, CH-1066 Epalinges, Switzerland Swiss Inst Expt Canc Res Chemin Boveresses 155 Epalinges Switzerland CH-1066
Citazione:
N. Cueille et al., "Flp1, a fission yeast orthologue of the S-cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis", J CELL SCI, 114(14), 2001, pp. 2649-2664

Abstract

In Saccharomyces cerevisiae, the phosphoprotein phosphatase Cdc14p plays acentral role in exit from mitosis, by promoting B-type cyclin degradation and allowing accumulation of the cyclin-dependent kinase inhibitor Sic1p. Cdc14p is sequestered in the nucleolus during interphase, from where it is released at the end of mitosis, dependent upon mitotic exit network function. The CDC14 gene is essential and loss-of-function mutants arrest at the end of mitosis. We have identified a fission yeast orthologue of CDC14 through database searches. A Schizosaccharomyces pombe flp1 (cdc (f) under bar ourteen-(l) under bar ike-(p) under bar hosphatase) null mutant is viable, divides at a reduced size and shows defects in septation. flp1p is not the essential effector of the S. pombe septation initiation network, but may potentiate signalling of the onset of septation. In contrast to S. cerevisiae Cdc14p, flp1p is not required for the accumulation or destruction of the B-type cyclin cdc13p, the cyclin-dependent kinase inhibitor rum1p, or for dephosphorylation of the APC/C specificity factor ste9p in G(1). Like its budding yeast counterpart, flp1p is restricted to the nucleolus until mitosis, when it is dispersed through the nucleus. In contrast to S. cerevisiae Cdc14p, ftp1p is also present on the mitotic spindle and contractile ring. The potential roles of flp1p in cell cycle control are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 09:45:19