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Titolo:
Distribution of K103N and/or Y181CHIV-1 mutations by exposure to zidovudine and non-nucleoside reverse transcriptase inhibitors
Autore:
Torti, C; Pozniak, A; Nelson, M; Hertogs, K; Gazzard, BG;
Indirizzi:
Chelsea & Westminster Hosp, St Stephen Ctr, Dept HIV GUM, London SW10 9TH,England Chelsea & Westminster Hosp London England SW10 9TH ndon SW10 9TH,England VIRCO, Mechelen, Belgium VIRCO Mechelen BelgiumVIRCO, Mechelen, Belgium
Titolo Testata:
Journal of antimicrobial chemotherapy
fascicolo: 1, volume: 48, anno: 2001,
pagine: 113 - 116
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANCE MUTATIONS; HIV-1 INFECTION; NEVIRAPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Torti, C Chelsea & Westminster Hosp, St Stephen Ctr, Dept HIV GUM, 4th Floor,369 Fulham Rd, London SW10 9TH, England Chelsea & Westminster Hosp 4th Floor,369 Fulham Rd London England SW10 9TH
Citazione:
C. Torti et al., "Distribution of K103N and/or Y181CHIV-1 mutations by exposure to zidovudine and non-nucleoside reverse transcriptase inhibitors", J ANTIMICRO, 48(1), 2001, pp. 113-116

Abstract

Our aim was to identify whether zidovudine has a role in the emergence of the K103N resistance mutation in the HIV-1 reverse transcriptase gene on non-nucleoside reverse transcriptase inhibitors (NNRTIs). No difference was found in the exposure to zidovudine or major zidovudine mutations between the resistance patterns K103N-N181C+, K103N+/Y181C- and K103N+/Y181C+, eitherin group A (patients on nevirapine and previously NNRTI naive) or in groupB (on any NNRTI and experience of two or more NNRTIs including nevirapine). Group B patients had the highest prevalence of K103N+/Y181C+. In conclusion, zidovudine seems not to determine the emergence of K103N; however, there appears to be an accumulation of NNRTI resistance mutations with sequential use of NNRTIs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:31:47