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Titolo:
Immune activation correlates better than HIV plasma viral load with CD4 T-cell decline during HIV infection
Autore:
Leng, QB; Borkow, G; Weisman, Z; Stein, M; Kalinkovich, A; Bentwich, Z;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Med Sch, Kaplan Med Ctr, Ruth Ben Ari InstClin Immunol, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel Hebrew Univ Jerusalem, Hadassah Med Sch, Kaplan Med Ctr, AIDS Ctr, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 27, anno: 2001,
pagine: 389 - 397
SICI:
1525-4135(20010801)27:4<389:IACBTH>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVE ANTIRETROVIRAL THERAPY; SYSTEM ACTIVATION; VIRUS; AIDS; LYMPHOCYTES; COUNTS; HOMEOSTASIS; TURNOVER; DISEASE; DYSREGULATION;
Keywords:
AIDS; CTLA-4; HAART; immune activation; Ki-67; viremia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Bentwich, Z Hebrew Univ Jerusalem, Hadassah Med Sch, Kaplan Med Ctr, Ruth Ben Ari InstClin Immunol, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 ehovot, Israel
Citazione:
Q.B. Leng et al., "Immune activation correlates better than HIV plasma viral load with CD4 T-cell decline during HIV infection", J ACQ IMM D, 27(4), 2001, pp. 389-397

Abstract

This study addressed the role of T-cell immune activation in determining HIV-I plasma viral load and CD4(+) T-cell blood levels during HIV-I infection. A decrease of blood CD4 levels and CD4/CD8 ratios and an increase of CD8levels in both treated (n = 35) and untreated (n = 19) HIV-positive individuals were more strongly correlated to immune activation (log percentage ofHLA-DR(+)CD3(+) cells; R = -0.78, R = -0.77. and R = 0.58, respectively: p< .0001) than to CD4 T-cell proliferation (log percentage of Ki-67(+)CD4(+) cells R = -0.57 [p < .0001], R = -0.48 [p < .001]. and R = 0.37 [p < .01]. respectively) or to viral load (R = -0.36 [P < .01], R = -0.23 [p = .09],R = 0.13 [p = .35], respectively). Because almost half of the Ki-67(+)CD4() cells were also positive for CTLA-4 (a marker for activated nonproliferating cells), the correlation of CD4 levels to Ki-67 expression is only partially related to cell proliferation and more likely represents mainly immune activation of the cells without proliferation. Taken together, these results suggest that immune activation is the major determinant of CD4 decline and should therefore be considered central for the monitoring of HIV infection and its outcome after antiviral treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:38:09