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Titolo:
Preliminary data of a prospective study on neuropsychiatric side effects after initiation of efavirenz
Autore:
Blanch, J; Martinez, E; Rousaud, A; Blanco, JL; Garcia-Viejo, MA; Peri, JM; Mallolas, J; De Lazzari, E; De Pablo, J; Gatell, JM;
Indirizzi:
Univ Barcelona, Hosp Clin Barcelona, Clin Inst Psychiat & Psychol, E-08036Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 Psychol, E-08036Barcelona, Spain Univ Barcelona, Hosp Clin Barcelona, Clin Inst Infect Dis & Microbiol, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 crobiol, E-08036 Barcelona, Spain Univ Barcelona, Hosp Clin Barcelona, Epidemiol & Biostat Unit,Fdn Clin Recerca Biomed, IDIBAPS, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 IDIBAPS, E-08036 Barcelona, Spain
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 27, anno: 2001,
pagine: 336 - 343
SICI:
1525-4135(20010801)27:4<336:PDOAPS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUALITY-OF-LIFE; SYMPTOMATIC HIV-INFECTION; ZIDOVUDINE TREATMENT; MEDICAL OUTCOMES; THERAPY; DISORDERS; TRIAL; AIDS;
Keywords:
efavirenz; neuropsychiatric; prospective; quality of life;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Blanch, J Univ Barcelona, Hosp Clin Barcelona, Clin Inst Psychiat & Psychol, Villarroel 170, E-08036 Barcelona, Spain Univ Barcelona Villarroel 170 Barcelona Spain E-08036 na, Spain
Citazione:
J. Blanch et al., "Preliminary data of a prospective study on neuropsychiatric side effects after initiation of efavirenz", J ACQ IMM D, 27(4), 2001, pp. 336-343

Abstract

Objective: To assess baseline variables able to predict neuropsychiatric side effects (NPSEs) associated with the initiation of an efavirenz (EFV)-containing regimen in HIV-1-infected patients. Design: Open-label, prospective, observational study. Methods: Consecutive HIV-1-infected outpatients in whom EFV was prescribedunderwent a psychiatric interview. At baseline and at 2, 4, and 12 weeks, patients completed the Symptoms Check List-90-Revised (SCL-90-R), the Medical Outcome Study for HIV-positive patients (MOS-HIV). and a standardized questionnaire concerning potential NPSEs. Results: Preliminary data showed that discontinuation of EFV because of NPSEs occurred in 4 of 31 patients (13%). Patients who completed the follow-up showed a decrease in SCL-90-R total score (p = .004) and in several subscales such as Interpersonal Sensitivity (p = .009). Depression (p = .001), and Anxiety (p = .040), whereas no changes in MOS-HIV were observed. Having fewer years of education (p = .006), having fewer baseline central nervous symptoms (p = .000), reporting better baseline physical status (p = .013), and having higher baseline scores in the Heath Transition subscale of the MOS-HIV (p = .000) and in the Somatization subscale of the SCL-90-R (p = .002) were associated with more NPSEs. Conclusion: Patients maintained on EFV showed a decrease in psychologic distress related to self-image, depression, and anxiety, without any effect on quality of life. Patients with a lower level of education, those who feelphysically and psychologically better at baseline than in the past, and those who suffer from more distress as a result of physical complaints may beat greater risk of reporting more NPSEs after EFV initiation.

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Documento generato il 19/01/20 alle ore 11:38:36