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Titolo:
Comparison of different treatment regimens for the emergence of new resistance under therapy
Autore:
Roberts, DE; Ribeiro, RM;
Indirizzi:
Univ Calif Los Alamos Natl Lab, Theoret Biol & Biophys Grp, Los Alamos, NM87545 USA Univ Calif Los Alamos Natl Lab Los Alamos NM USA 87545 lamos, NM87545 USA Florida State Univ, Tallahassee, FL 32306 USA Florida State Univ Tallahassee FL USA 32306 iv, Tallahassee, FL 32306 USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 4, volume: 27, anno: 2001,
pagine: 331 - 335
SICI:
1525-4135(20010801)27:4<331:CODTRF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-RESISTANCE; ANTIRETROVIRAL THERAPY; HIV-1 INFECTION; REVERSE-TRANSCRIPTASE; GENOTYPIC RESISTANCE; VIRAL DYNAMICS; TRANSMISSION; LOAD;
Keywords:
antiretroviral therapy; HIV drug resistance; mathematical models; treatment efficacy; genotypic testing; HIV quasispecies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Ribeiro, RM Univ Calif Los Alamos Natl Lab, Theoret Biol & Biophys Grp, MSK710, Los Alamos, NM 87545 USA Univ Calif Los Alamos Natl Lab MS K710 Los Alamos NM USA 87545
Citazione:
D.E. Roberts e R.M. Ribeiro, "Comparison of different treatment regimens for the emergence of new resistance under therapy", J ACQ IMM D, 27(4), 2001, pp. 331-335

Abstract

Objective: To compare the effects of different therapy regimens on the probability of emergence of new resistant mutants during therapy. Methods: We developed a stochastic model of infection and treatment to calculate the probability of de novo resistance during therapy. We simulated diverse treatment regimens. with different efficacy in controlling HIV replication. We studied the use of genotypic testing to choose treatment protocols specifically tailored against the wild type. Results: The probability of emergence of a previously nonexisting drug-resistant mutant during therapy depends crucially on the drug regimen used. lnparticular, therapy protocols targeting the wild-type strain may lead to ahigher probability of treatment failure due to resistance. Conversely, targeting the minority strains in the population. which readily mutate into the resistant variety. significantly lowers the probability of a new resistant emerging under therapy. Conclusions: Use of genotypic testing may lead to wrong decisions in the choice of therapy if the population dynamics of production of new resistant mutants is not taken into account.

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Documento generato il 23/01/20 alle ore 03:21:21