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Titolo:
Effects of L-arginine on penicillin-induced epileptiform activity in rats
Autore:
Marangoz, C; Bagirici, F;
Indirizzi:
Ondokuz Mayis Univ, Fac Med, Dept Physiol, TR-55139 Kurupelit, Turkey Ondokuz Mayis Univ Kurupelit Turkey TR-55139 TR-55139 Kurupelit, Turkey
Titolo Testata:
JAPANESE JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 86, anno: 2001,
pagine: 297 - 301
SICI:
0021-5198(200107)86:3<297:EOLOPE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CENTRAL-NERVOUS-SYSTEM; NMDA RECEPTORS; ANTICONVULSANT; MICE; INVOLVEMENT; INHIBITION; EPILEPSY; SEIZURE; MODEL;
Keywords:
nitric oxide; L-arginine; sodium nitroprusside; 7-nitroindazole; epileptiform activity; penicillin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Bagirici, F Ondokuz Mayis Univ, Fac Med, Dept Physiol, TR-55139 Kurupelit,Turkey Ondokuz Mayis Univ Kurupelit Turkey TR-55139 rupelit, Turkey
Citazione:
C. Marangoz e F. Bagirici, "Effects of L-arginine on penicillin-induced epileptiform activity in rats", JPN J PHARM, 86(3), 2001, pp. 297-301

Abstract

It has been suggested that nitric oxide (NO) is involved in the pathophysiology of epilepsy. Data are, however controversial because it is not clear whether NO has pro- or anticonvulsant effects. The aim of this study was toinvestigate the effects of NO on penicillin G-induced epileptiform activity. The left cerebral cortex was exposed by craniotomy in urethane-anesthetized Wistar rats. The epileptic activity was produced by intraperitoneal injection of penicillin G (3 million U/kg, i.p.). The ECoG (electrocorticogram.) activity was displayed on a four-channel recorder. At 39.7 +/- 5.4 min after penicillin administration, large amplitude sharp waves appeared in theECoG. Mean spike frequency and mean spike amplitude were calculated as 29.5 +/- 3.2/min and 865 +/- 91 muV, respectively, at the 55th min. 7-Nitroindazole (60 mg/kg, i.p.) injection 30 min before penicillin G administration significantly reduced the latency of epileptiform activity. Intracerebroventricular administration of L-arginine (300 mug/2 mul, i.c.v.) and sodium nitroprusside (100 mug /2 mul, i.c.v.) suppressed epileptiform activity. Saline (2 mul) and D-arginine (300 mug/2 mul, i.c.v.) administration into the cerebral ventricle were completely ineffective on epileptiform. activity (P<0.01). These findings suggest that NO may be an endogenous antiepileptic substance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:05:01