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Titolo:
Intracavitary chemotherapy with 5-fluoro-2 '-deoxyuridine (FdUrd) in malignant brain tumors
Autore:
Nakagawa, H; Maeda, N; Tsuzuki, T; Suzuki, T; Hirayama, A; Miyahara, E; Wada, K;
Indirizzi:
Osaka Med Ctr Canc & Cardiovasc Dis, Dept Neurosurg, Higashinari Ku, Osaka5378511, Japan Osaka Med Ctr Canc & Cardiovasc Dis Osaka Japan 5378511 ka5378511, Japan
Titolo Testata:
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
fascicolo: 6, volume: 31, anno: 2001,
pagine: 251 - 258
SICI:
0368-2811(200106)31:6<251:ICW5'(>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MENINGEAL DISSEMINATION; FLUOROURACIL;
Keywords:
5-fluoro-2 '-deoxyuridine; intracavitary chemotherapy; malignant brain tumor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Nakagawa, H Osaka Med Ctr Canc & Cardiovasc Dis, Dept Neurosurg, Higashinari Ku, 3 Nakamichi 1 Chome, Osaka 5378511, Japan Osaka Med Ctr Canc & Cardiovasc Dis 3 Nakamichi 1 Chome Osaka Japan 5378511
Citazione:
H. Nakagawa et al., "Intracavitary chemotherapy with 5-fluoro-2 '-deoxyuridine (FdUrd) in malignant brain tumors", JPN J CLIN, 31(6), 2001, pp. 251-258

Abstract

Background: After completing basic research on the anti-tumor effects and neurotoxicity of 5-fluoro-2'-deoxyuridine (FdUrd) and the balance of thymidine kinase and thymidine phosphorylase activities and confirming the safetyof intrathecal FdUrd administration in a previous clinical study of meningeal carcinomatosis, intracavitary administration of FdUrd was performed as a second trial in patients with malignant glioma and metastatic brain tumors. Methods: The study population consisted of 13 patients, six with glioblastoma, one with anaplastic astrocytoma and six with metastatic brain tumors. This treatment was applied for cystic, small-volume residual or recurrent tumors. FdUrd (1-10 mug) was administered every day at least 25 times through an Ommaya device placed in the cyst or closed postoperative cavity reconstructed with a patch of galea aponeurotica. Intracavitary chemotherapy withFdUrd was preceded by radiation therapy in two patients but no other adjuvant therapy was performed. Results: No side effects such as headache, nuchal pain, convulsive attack,bone marrow suppression or liver dysfunction were observed during the course of chemotherapy. Seven of the 13 patients showed responses: complete response six, minor response one, no change two and progressive disease four after the twenty-fifth intracavitary administration of FdUrd when tumor sizes on CT scans and MRI before and after intracavitary chemotherapy were compared. Conclusions: Intracavitary FdUrd chemotherapy may be useful for the treatment of small-volume tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 20:09:24