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Titolo:
Expression of ICAD-L and ICAD-S in human brain tumor and its cleavage uponactivation of apoptosis by anti-Fas antibody
Autore:
Masuoka, F; Shiraishi, T; Ichinose, M; Mineta, T; Tabuchi, K;
Indirizzi:
Saga Med Sch, Dept Neurosurg, Saga 8498501, Japan Saga Med Sch Saga Japan 8498501 Sch, Dept Neurosurg, Saga 8498501, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 7, volume: 92, anno: 2001,
pagine: 806 - 812
SICI:
0910-5050(200107)92:7<806:EOIAII>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA FRAGMENTATION; CELL-DEATH; INHIBITOR; CASPASES; DEGRADATION; NUCLEASE;
Keywords:
ICAD/DFF; CAD/DFF40; brain tumor; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Shiraishi, T Saga Med Sch, Dept Neurosurg, 5-1-1 Nabeshima, Saga 8498501, Japan Saga Med Sch 5-1-1 Nabeshima Saga Japan 8498501 98501, Japan
Citazione:
F. Masuoka et al., "Expression of ICAD-L and ICAD-S in human brain tumor and its cleavage uponactivation of apoptosis by anti-Fas antibody", JPN J CANC, 92(7), 2001, pp. 806-812

Abstract

ICAD/DFF is a downstream molecule of caspases, participating in nuclear DNA fragmentation during apoptosis. ICAD/DFF binds CAD/DFF40 and inhibits itsDNase activity. ICAD/DFF has two alternative isoforms, long isoform (ICAD-L/DFF45) and short isoform (ICAD-S/DFF35). We have studied the presence andfunctional status of ICAD/DFF in human glioma cell lines. All cell lines tested expressed both ICAD-L and ICAD-S. When the cultured glioma cells wereexposed to anti-Fas antibody, these isoforms were degraded prior to the fragmentation of the nuclear DNA, indicating that the ICAD/DFF expressed in cultured glioma cells was potentially functional. In primary brain tumors and normal brain tissues, there was a difference in the expression level between ICAD-L and ICAD-S. In glioblastomas, ICAD-S was more abundant than ICAD-L. In contrast, ICAD-L was more abundant than ICAD-S in medulloblastomas. The present findings suggest that primary brain tumors and normal brain constitutively express ICAD/DFF, and that there is a difference between the expression levels of ICAD-L and ICAD-S.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:54:37