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Titolo:
Combined magnetic resonance imaging and single-photon emission tomography scanning in the discrimination of Alzheimer's disease from age-matched controls
Autore:
OBrien, JT; Ames, D; Desmond, P; Lichtenstein, M; Binns, D; Schweitzer, I; Davis, S; Tress, B;
Indirizzi:
Univ Newcastle Upon Tyne, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England Univ Newcastle Upon Tyne Newcastle Upon Tyne Tyne & Wear England NE1 7RU Univ Melbourne, Royal Melbourne Hosp, Dept Psychiat, Melbourne, Vic 3050, Australia Univ Melbourne Melbourne Vic Australia 3050 elbourne, Vic 3050, Australia Univ Melbourne, Royal Melbourne Hosp, Dept Neurol, Melbourne, Vic 3050, Australia Univ Melbourne Melbourne Vic Australia 3050 elbourne, Vic 3050, Australia Univ Melbourne, Royal Melbourne Hosp, Dept Radiol, Melbourne, Vic 3050, Australia Univ Melbourne Melbourne Vic Australia 3050 elbourne, Vic 3050, Australia Univ Melbourne, Royal Melbourne Hosp, Dept Nucl Med, Melbourne, Vic 3050, Australia Univ Melbourne Melbourne Vic Australia 3050 elbourne, Vic 3050, Australia
Titolo Testata:
INTERNATIONAL PSYCHOGERIATRICS
fascicolo: 2, volume: 13, anno: 2001,
pagine: 149 - 161
SICI:
1041-6102(200106)13:2<149:CMRIAS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; HIPPOCAMPAL ATROPHY; COGNITIVE PERFORMANCE; GLUCOSE-METABOLISM; DIAGNOSIS; DEMENTIA; SPECT; QUANTIFICATION; DEPRESSION; VOLUME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: O'Brien, JT Newcastle Gen Hosp, Wolfson Res Ctr, Westgate Rd, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England Newcastle Gen Hosp Westgate Rd Newcastle Upon Tyne Tyne & Wear England NE4 6BE
Citazione:
J.T. O'Brien et al., "Combined magnetic resonance imaging and single-photon emission tomography scanning in the discrimination of Alzheimer's disease from age-matched controls", INT PSYCHOG, 13(2), 2001, pp. 149-161

Abstract

Objective: To compare the utility of temporal lobe magnetic resonance imaging (MRI) and single-photon emission tomography (SPET) scanning in discriminating between subjects with Alzheimer's disease (AD) and age-matched controls. Methods: Thirty subjects with NINCDS-ADRDA AD (23 probable AD, 5 possible AD, 2 definite AD) and 22 age- and sex-matched controls underwent TI-weighted coronal MRI scanning (0.3 T) and technetium 99m-HMPAO SPET scanning. MRI scans were analyzed using a digitizer system with volumes of hippocampus, amygdala, entorhinal cortex, parahippocampal gyrus, and whole cerebral cortex calculated. From SPET scans, regional cerebral blood flow (rCBF) wasassessed in anterior and posterior frontal, parietal, occipital, and mesial temporal cortex using a region of interest analysis with the cerebellum as a reference area. Results: Using MRI, the areas that best separated groups were left hippocampal and left amygdala volume, resulting in correct classification (patient vs. control) in 79% of cases (sensitivity 77%, specificity 82%). Exactly the same proportion of subjects were correctly classifiedby SPET, with the most discriminating rCBF changes being left parietal andright posterior frontal. Combining information from both scans improved the proportion of correctly classified subjects in a discriminant function to90% (sensitivity 93%, specificity 86%; only 2 AD and 3 controls misclassified). All AD subjects had abnormalities on MRI and/or SPET (sensitivity forcombined examinations 100%), while abnormalities on both MRI and SPET had a positive predictive value of 100% for dementia (including the detection of one control subject who later had dementia). Significant correlations between MRI and SPET measures were seen in control subjects but not in patients. Conclusion: Both 0.3 T MRI and single rotating gamma camera SPET were equally useful in separating AD subjects from age-matched controls, although the combination of both significantly enhanced discrimination. In particular, all AD subjects had abnormalities on either MRI or SPET and both techniques may have an important role in assisting with clinical diagnosis, thoughreplication in other centers and examination of differentiation of AD fromother causes of dementia need to be examined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 18:12:10