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Titolo:
Induction of apoptosis by cyclooxygenase-2 inhibitors in prostate cancer cell lines
Autore:
Kamijo, T; Sato, T; Nagatomi, Y; Kitamura, T;
Indirizzi:
Univ Tokyo, Fac Med, Dept Urol, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 ept Urol, Bunkyo Ku, Tokyo 1138655, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF UROLOGY
fascicolo: 7, volume: 8, anno: 2001,
pagine: S35 - S39
SICI:
0919-8172(200107)8:7<S35:IOABCI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-BREAST-CANCER; HUMAN COLON-CANCER; DIFFERENTIAL EXPRESSION; PROSTAGLANDIN E-2; FATTY-ACIDS; CARCINOGENESIS; PHOSPHOLIPIDS; CARCINOMA; BENIGN;
Keywords:
apoptosis; cyclooxygenase-2 (COX-2); non-steroidal anti-inflammatory drugs; prostate cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kamijo, T Univ Tokyo, Fac Med, Dept Urol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138655 Tokyo 1138655, Japan
Citazione:
T. Kamijo et al., "Induction of apoptosis by cyclooxygenase-2 inhibitors in prostate cancer cell lines", INT J UROL, 8(7), 2001, pp. S35-S39

Abstract

Prostaglandins are thought to play an important role in the proliferation of prostate cancer and are highly expressed in prostate cancer tissue. Cyclooxygenase-2 (COX-2), or prostaglandin endoperoxide synthase, is a key enzyme in the conversion of arachidonic acid into prostaglandin. In several cancers, COX-2 contributes to the proliferation and metastasis of cancer cells. To assess the role of COX-2 in prostate cancer, we investigated whether the inhibition of COX-2 affected the proliferation of prostate cancer cells. The human prostate cancer cell lines, LNCaP and PC 3, and a normal prostate stromal cell line (PrSC) were treated with COX-2 inhibitors NS 398 and Etodolac. The proliferation rate of the cell lines was examined using 3(4,5-dimethylethiazoly 1-2-) 2,5-diphonyl tetrazolium bromide (MTT) assays. A DNAfragmentation assay was also used for proof of apoptosis. COX-2 inhibitorscould suppress the proliferation of LNCaP and PC 3 cells. In contrast, PrSC was not affected by COX-2 inhibitors. These suppressive effects occurred in a time- and dose-dependent manner. One of mechanisms responsible for cell death was apoptosis. COX-2 seems to play a significant role in the progression of prostate cancer. COX-2 may be a therapeutic target for prostate cancer. Since COX-2 inhibitors suppress proliferation and induce apoptosis inprostate cancer cells, and have no effect in normal prostate stromal cells, COX-2 inhibitors will be useful for the treatment of prostate cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:42:51