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Titolo:
Intranuclear ubiquitin immunoreactivity in the pigmented neurons of the substantia nigra in fire fatalities
Autore:
Quan, L; Zhu, BL; Oritani, S; Ishida, K; Fujita, MQ; Maeda, H;
Indirizzi:
Osaka City Univ, Sch Med, Dept Legal Med, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 Dept Legal Med, Osaka 5458585, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
fascicolo: 6, volume: 114, anno: 2001,
pagine: 310 - 315
SICI:
0937-9827(200107)114:6<310:IUIITP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK-PROTEIN; TRAUMATIC BRAIN INJURY; ISCHEMIC BRAIN; MESSENGER-RNA; NEURODEGENERATIVE DISEASES; AXONAL INJURY; C-FOS; HYPERTHERMIA; EXPRESSION; STRESS;
Keywords:
ubiquitin; pigmented substantia nigra neurons immunohistochemistry; fire fatality; physical activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Quan, L Osaka City Univ, Sch Med, Dept Legal Med, Asahimachi 1-4-3, Osaka 5458585,Japan Osaka City Univ Asahimachi 1-4-3 Osaka Japan 5458585 458585,Japan
Citazione:
L. Quan et al., "Intranuclear ubiquitin immunoreactivity in the pigmented neurons of the substantia nigra in fire fatalities", INT J LEGAL, 114(6), 2001, pp. 310-315

Abstract

To evaluate the significance of immunohistochemical staining of ubiquitin (heat shock protein) in the midbrain for medico-legal investigation of death in fires. we examined forensic autopsy cases of fire fatalities (n = 35) in comparison with controls (n = 27; brain stem injury, acute myocardial infarction and carbon monoxide poisoning other than fire fatality). There were two intranuclear staining patterns in the nuclei of pigmented substantia nigra neurons: a type of inclusion (possible Marinesco bodies) and a diffuse staining. Percentage of nuclear ubiquitin positivity (Ub-positive %) in fire fatalities (2.7-44.7%; mean, 18.5%) was significantly higher than in brain stem injury (n = 9; 0-10.4%; mean, 4.5%) and myocardial infarction (n =14; 1.5-14.6%; mean, 6.9%), independently of blood carboxyhemoglobin (COHb) levels. Age-dependent increase in Ub-positive % was observed in lower COHb (< 60%) cases. The intranuclear diffuse ubiquitin staining was not observed in cases of high blood cyanide level (> 1.0 mug/ml). These observations showed that intranuclear ubiquitin immunoreactivity of the pigmented substantia nigra neurons in the midbrain was induced by severe stress in fires.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:46:28