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Titolo:
A conscious-rabbit model to study vardenafil hydrochloride and other agents that influence penile erection
Autore:
Bischoff, E; Schneider, K;
Indirizzi:
Bayer AG, Pharmaceut Business Grp, Inst Cardiovasc Res 2, D-42096 Wuppertal, Germany Bayer AG Wuppertal Germany D-42096 asc Res 2, D-42096 Wuppertal, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
fascicolo: 4, volume: 13, anno: 2001,
pagine: 230 - 235
SICI:
0955-9930(200108)13:4<230:ACMTSV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; DYSFUNCTION; STIMULATION; PHYSIOLOGY;
Keywords:
penile erection; PDE5 inhibitor; rabbit; erectile dysfunction; impotence; vardenafil;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Bischoff, E Bayer AG, Pharmaceut Business Grp, Inst Cardiovasc Res 2, POB 101709, D-42096 Wuppertal, Germany Bayer AG POB 101709 Wuppertal Germany D-42096 pertal, Germany
Citazione:
E. Bischoff e K. Schneider, "A conscious-rabbit model to study vardenafil hydrochloride and other agents that influence penile erection", INT J IMPOT, 13(4), 2001, pp. 230-235

Abstract

Experimental models to study the effect of agents on penile erection usually include electrical stimulation of peripheral nerves in anesthetized animals combined with systemic or intracavernous injection of drugs. The objective of this study was to demonstrate that conscious rabbits can be used as a simple and quantitative model for the assessment of compounds that show potential for the treatment of erectile dysfunction. Erection was assessed by measuring the length of uncovered penile mucosa before and after the intravenous (i.v.) administration of agents. Animals did not require anesthesiaduring the course of the study. The phosphodiesterase 5 (PDE5) inhibitors vardenafil x HCl (hereafter called vardenafil) and sildenafil were given intravenously, and measurements were taken for 0-5 h. The effects of phentolamine and milrinone were also evaluated. Vardenatil (0.1-3 mg/kg) induced dose-dependent penile erections in conscious rabbits following i.v. administration. The efficacy of vardenafil was potentiated, and the minimal effective dose was reduced significantly to 0.01 mg/kg by simultaneous administration of the nitric oxide (NO) donor sodium nitroprusside (SNP). Administration of the NO-synthase inhibitor L-NAME abolished the effect, Sildenafil was effective in this model after Lv. administration. The a-adrenergic receptorantagonist phentolamine (0.1, 0.3 and 1 mg/kg i.v.) induced erections witha slower t(max) compared with vardenafil and sildenafil. Intravenous administration of the PDE3 inhibitor milrinone (1 mg/kg i.v.) was less effectivethan the PDE5 inhibitor vardenafil. The conscious rabbit is a suitable andreliable model for the evaluation of compounds with potential for the treatment of erectile dysfunction. This was demonstrated using compounds that target different signaling pathways that induce smooth muscle relaxation in the penis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:20:07