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Titolo:
ASSESS-3*: A randomised, double-blind, flexible-dose clinical trial of theefficacy and safety of oral sildenafil in the treatment of men with erectile dysfunction in Taiwan
Autore:
Chen, KK; Hsieh, JT; Huang, ST; Jiaan, DBP; Lin, JSN; Wang, CJ;
Indirizzi:
Vet Gen Hosp, Dept Surg, Taipei 112, Taiwan Vet Gen Hosp Taipei Taiwan 112 t Gen Hosp, Dept Surg, Taipei 112, Taiwan Natl Taiwan Univ Hosp, Taipei, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan tl Taiwan Univ Hosp, Taipei, Taiwan Chang Gung Mem Hosp, Tao Yuan, Taiwan Chang Gung Mem Hosp Tao Yuan Taiwan ang Gung Mem Hosp, Tao Yuan, Taiwan Kaohsiung Vet Gen Hosp, Kaohsiung, Taiwan Kaohsiung Vet Gen Hosp Kaohsiung Taiwan Vet Gen Hosp, Kaohsiung, Taiwan Natl Cheng Kung Univ, Coll Med, Tainan 70101, Taiwan Natl Cheng Kung UnivTainan Taiwan 70101 Coll Med, Tainan 70101, Taiwan Kaohsiung Med Univ, Kaohsiung, Taiwan Kaohsiung Med Univ Kaohsiung Taiwan ohsiung Med Univ, Kaohsiung, Taiwan
Titolo Testata:
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
fascicolo: 4, volume: 13, anno: 2001,
pagine: 221 - 229
SICI:
0955-9930(200108)13:4<221:AARDFC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PSYCHOGENIC IMPOTENCE; VIAGRA; ALPROSTADIL; TRAZODONE; YOHIMBINE;
Keywords:
erectile dysfunction; sildenafil; efficacy; safety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, KK Vet Gen Hosp, Dept Surg, No 201,Sec 2 Shih Pai Rd, Taipei 112, Taiwan Vet Gen Hosp No 201,Sec 2 Shih Pai Rd Taipei Taiwan 112 , Taiwan
Citazione:
K.K. Chen et al., "ASSESS-3*: A randomised, double-blind, flexible-dose clinical trial of theefficacy and safety of oral sildenafil in the treatment of men with erectile dysfunction in Taiwan", INT J IMPOT, 13(4), 2001, pp. 221-229

Abstract

The efficacy and safety of sildenafil were evaluated in a randomised, double-blind, placebo-controlled, flexible-dose study in Taiwanese men aged 26 to 80 y with erectile dysfunction (ED) of broad-spectrum aetiology and morethan 6 months' duration. A total of 236 patients were randomised at six medical centres in Taiwan to receive either sildenafil (50 mg initially increased if necessary to 100 mg or decreased to 25 mg depending on efficacy andtoleration) (n = 119) or matching placebo (n = 117) taken on an 'as needed' basis 1 h prior to anticipated sexual activity for a period of 12 weeks. At the end of 12 weeks, the primary efficacy variables relating to the achievement and maintenance of erections sufficient for sexual intercourse, andthe secondary efficacy variables, which included: (1) the five separate domains of sexual functioning of the IIEF (International Index of Erectile Function) scale, (2) the percentage of successful intercourse attempts; and (3) a global assessment of erections, were all statistically significantly improved by sildenafil in comparison with placebo (P<0.0001). Treatment-related adverse events occurred in 43.7% of patients receiving sildenafil and 18.8% receiving placebo. The most common adverse events with sildenafil wereRushing, dizziness and headache (25.2, 6.7 and 5.9% of patients, respectively), and most were mild in nature. The efficacy and safety of sildenafil in the population of Taiwanese men appears similar to that reported in otherstudies in western populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 08:23:00