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Titolo:
Effects of estrogen on nitric oxide synthase and histological composition in the rabbit clitoris and vagina
Autore:
Yoon, HN; Chung, WS; Park, YY; Shim, BS; Han, WS; Kwon, SW;
Indirizzi:
Med Res Ctr, Dept Urol, Seoul, South Korea Med Res Ctr Seoul South Korea ed Res Ctr, Dept Urol, Seoul, South Korea Ewha Womans Univ, Coll Med, Dept Pathol, Seoul, South Korea Ewha Womans Univ Seoul South Korea Med, Dept Pathol, Seoul, South Korea
Titolo Testata:
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
fascicolo: 4, volume: 13, anno: 2001,
pagine: 205 - 211
SICI:
0955-9930(200108)13:4<205:EOEONO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ERECTILE FUNCTION; DOWN-REGULATION; SMOOTH-MUSCLE; SEX-HORMONES; NERVE-FIBERS; GUINEA-PIG; UTERUS; INDUCTION; UTERINE; EXPRESSION;
Keywords:
estrogen; NOS; clitoris; vagina; smooth muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, WS Ewha Womans Univ, Mokdong Hosp, Dept Urol, 911-1 Mokdong, Seoul 158710, South Korea Ewha Womans Univ 911-1 Mokdong Seoul South Korea 158710 h Korea
Citazione:
H.N. Yoon et al., "Effects of estrogen on nitric oxide synthase and histological composition in the rabbit clitoris and vagina", INT J IMPOT, 13(4), 2001, pp. 205-211

Abstract

We investigated the functional and histological changes after oophorectomyin the rabbit clitoris and vagina to determine the mechanism responsible for the development of arousal disorder in postmenopausal women. Twenty mature female New Zealand white rabbits were randomly divided into three groups. control; oophorectomy; and estrogen replacement after oophorectomy. We compared the nitric oxide synthase (NOS) activity and the degree of expression of neuronal (nNOS) and endothelial NOS (eNOS) using biochemical and Western blot analysis in clitoral and vaginal tissues. Histological change of smooth muscle and collagen contents in those tissues were also compared usingMasson's trichrome staining. NOS activity and the expression of nNOS and eNOS were significantly increased in the oophorectomized group while there was a decrease to the level of the control group in the estrogen replacementgroup. Histological examination showed that oophorectomy induced a significant increase in collagen and decrease in muscle content in both clitoris and vagina, while the ratio of smooth muscle content was increased significantly after the estrogen replacement. Our results clearly demonstrate that estrogen deficiency induces compensatory NOS production which may be relatedto decreases in muscle to collagen ratio in female rabbit genital organs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 14:25:25