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Titolo:
Hypothalamic-pituitary-thyroidal axis dysfunction and cortisol secretion in patients with nonclassical congenital adrenal hyperplasia
Autore:
Trakakis, E; Chryssikopoulos, A; Sarandakou, A; Phocas, I; Rizos, D; Gregoriou, O; Kontoravdis, A; Creatsas, G;
Indirizzi:
Univ Athens, Dept Obstet & Gynecol 2, GR-11528 Athens, Greece Univ AthensAthens Greece GR-11528 & Gynecol 2, GR-11528 Athens, Greece Arete Univ Hosp, Hormonol Lab, Athens, Greece Arete Univ Hosp Athens Greece e Univ Hosp, Hormonol Lab, Athens, Greece
Titolo Testata:
INTERNATIONAL JOURNAL OF FERTILITY AND WOMENS MEDICINE
fascicolo: 1, volume: 46, anno: 2001,
pagine: 37 - 41
SICI:
1534-892X(200101/02)46:1<37:HADACS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; 21-HYDROXYLASE DEFICIENCY; 21-ALPHA-HYDROXYLASE DEFICIENCY; THYROTROPIN SECRETION; ADDISONS-DISEASE; DIAGNOSIS; STRESS; WOMEN;
Keywords:
21-hydroxylase deficiency; ACTH secretion; infertility (female);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Chryssikopoulos, A Univ Athens, Arete Hosp, Dept Obstet & Gynecol 2, 86 Vas Sophias Ave, GR-11528 Athens, Greece Univ Athens 86 Vas Sophias Ave Athens Greece GR-11528
Citazione:
E. Trakakis et al., "Hypothalamic-pituitary-thyroidal axis dysfunction and cortisol secretion in patients with nonclassical congenital adrenal hyperplasia", INT J F W M, 46(1), 2001, pp. 37-41

Abstract

Objective-The purpose of this study was to evaluate thyroid function and TSH and cortisol (F) secretion in hyperandrogenemic women with nonclassical congenital adrenal hyperplasia (NC-CAH) due to 21-hydroxylase deficiency (Group A) when compared with women with hyperandrogenemic symptoms (menstrualirregularities, hirsutism, acne, seborrhea and sterility) of other etiologies (Group B). Methods-Seventy-two women were subjected to stimulation of the adrenal cortex with i.v. ACTH administration in the early proliferative phase of the menstrual cycle. Basal plasma TSH, T-3, T-4, and FTI as well as basal and ACTH-stimulated plasma F and 17-hydroxyprogesterone levels weredetermined. Results-According to internationally accepted criteria and HLAhaplotyping, we diagnosed 28 NC-CAH patients as well as affected heterozygotes of the disease. No significant difference was found in the plasma T3, T4, or FTI or F concentrations between the women of the two groups. On the contrary, plasma TSH levels were significantly lower in patients with 21-hydroxylase deficiency when compared to the women with hyperandrogenemic symptoms of other etiologies. Conclusion-The results of this study support a dysfunction of the hypothalamic-pituitary-thyroidal axis due to altered ACTH secretion patterns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:49:24